MOLECULAR AND CELLULAR PHARMACOLOGY

GRADUATE STUDENTS ACHIEVEMENTS

(2002-2006)

Graduate Program Director: Styliani-Anna Tsirka

Department Chair: Jeffrey Pessin

Baniecki, Mary Lynn  (2002) Van der Kloot Award for Excellence in Research in the Graduate Program in Molecular and Cellular Pharmacology, $500.

Bonsra, Akua (2004-2008) W. Burghardt Turner Fellow

Caces, Donne Bennett (2005) Van der Kloot Award for Excellence in Teaching in the Graduate Program in Molecular and Cellular Pharmacology, $500.

Feigin, Michael (2005) Graduate Program in Molecular and Cellular Pharmacology Annual Symposium’s “Snapshot” Award, $75, Stony Brook, NY, USA

Gravanis, Iordanis (2003) Van der Kloot Award for Excellence in Teaching in the Graduate Program in Molecular and Cellular Pharmacology, $500.

Gravanis, Iordanis. (2004-05) Dr. Fredrick Valergakis Graduate Research Grant, $1000, Hellenic University Club of New York, New York, NY

Gravanis, Iordanis (2006). Graduate Council Commendation for Excellence in Teaching by Graduate Student, Stony Brook, NY, USA

Mirrione, Martine (2003) Graduate Program in Molecular and Cellular Pharmacology Annual Symposium’s “Best Experiment” Award, $75.

Mirrione, Martine (2005).  3^rd Place in Poster Competition at the Xth International Workshop on Molecular and Cellular Biology of Plasminogen Activation.  $100.

Ocampo, Christopher (2002) Van der Kloot Award for Excellence in Teaching in the Graduate Program in Molecular and Cellular Pharmacology, $500.

Ocampo, Christopher   (2003-2006).  Ruth L. Kirschstein NRSA:  Minority Predoctoral Fellowship (F31).  NIH National Institute of Allergy and Infectious Diseases.  Bethesda, MD.  $20,772/year.

Peng, Yinan (2004) - Yinan Peng's paper (Advisor: Dr. David Williams) on Scavenging Cholesterol - Mol. Biol. Cell 15, 384 (2004) has made Science's Editors' Choice: Highlights of the recent literature Science, 303, 2004

Peng, Yinan (2004) Van der Kloot Award for Excellence in Research in the Graduate Program in Molecular and Cellular Pharmacology, $500.

Parathath, Saj (2003) Certificate of Recognition presented by the Alliance for Graduate Education and the Professoriate (AGEP) for serving as a Research Mentor in the Summer Research Institute.

Parathath, Saj (2004) Tie for “Best Poster” Award presented at the Graduate Program in Molecular and Cellular Pharmacology’s Annual Fall Symposium, Old Field Club, Stony Brook, NY, September 9.   $75.

Sheehan, John (2002) “Best Poster” Award presented at the Graduate Program in Molecular and Cellular Pharmacology’s Annual Fall Symposium, Old Field Club, Stony Brook, NY, September 12.  $75.

Sheehan, John (2003) Certificate of Recognition presented by the Alliance for Graduate Education and the Professoriate (AGEP) for serving as a Research Mentor in the Summer Research Institute.

Siao, Chia-Jen (Jean) (2002) SUNYSB Chapter of Sigma Xi Excellence in Research Award.

Siao, Chia-Jen (Jean) (2002) Institute for Cell and Developmental Biology Excellence in Research Award, $500.

Staresincic, Lidija (2006) Molecular Cell" poster prize on "Coordination of Dual Incision and Repair Synthesis in Human Nucleotide Excision Repair" at the meeting: “from Molecular Mechanism to Human Disorders” in the Netherlands.

Strockbine, Bentley (2003) The Chemical Computing Group’s Excellence Award from the American Chemical Society’s Division of Computers in Chemistry, presented at the Spring 2003 ACS National Meeting in New Orleans, entitled Advances in Structure Prediction Techniques (Advisor: Carlos Simmerling). $1,200 Travel Award.

Su, Wenjuan (2005)  Van der Kloot Award for Excellence in Research in the Graduate Program in Molecular and Cellular Pharmacology, $500

Watkins, Jermel  (2004) Tie for “Best Poster” Award presented at the Graduate Program in Molecular and Cellular Pharmacology’s Annual Fall Symposium, Old Field Club, Stony Brook, NY, September 9.   $75.

Watkins, Jermel.  (2005) Turner Dissertation Fellowship, $10,000.

Weston, Christi (2003) Van der Kloot Award for Excellence in Research in the Graduate Program in Molecular and Cellular Pharmacology, $500

Weston, Christi (2003-2004) Institute for Cell and Developmental Biology Predoctoral Fellowship, SUNY at Stony Brook, $22,000

Weston, Christi (2004-2007) Ruth L. Kirschstein National Research Award, National Institute of Neurological Disorders and Stroke, “Regulation of Neuromuscular Synaptogenesis”

Yondola, Mark (2004) “Best Experiment” Award, presented at the Graduate Program in Molecular and Cellular Pharmacology’s Annual Fall Symposium, Old Field Club, Stony Brook, NY, September 9. $75.

Zhang, Yan (2002) Graduate Program in Molecular and Cellular Pharmacology Annual Symposium’s “Best Experiment” Award, $75.

Zhang, Yan (2003) Elected Associate Member of the Sigma Xi Scientific Research Society

PUBLICATIONS

Baniecki, Mary Lynn, McGrath, W.J., Dauter, Z., and Mangel, W.F. (2002) Adenovirus proteinase: crystallization and preliminary X-ray diffraction studies to atomic resolution. Acta Crystallographica Section D-Biological Crystallography. 58:1462-4.

Brown, Mark T., McBride, K.M., Baniecki, Mary Lynn, Reich, N.C., Marriott, G., and Mangel, W.F. (2002) Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton. J. Biol. Chem. 277:46298-303.

Procino, G., Donne Bennett Caces, G. Valenti, and J.E. Pessin (2006) Adipocytes support cAMP-dependent translocation of aquaporin-2 from intracellular sites distince from the insulin-responsive GLUT4 storage compartment. Am. J. Physiol. Renal Physiol. 290: F985-94

Connolly JE, Engebrecht J. (2006) The Arf-GTPase-activating protein Gcs1p is essential for sporulation and regulates the phospholipase D Spo14p. Eukaryot Cell. 5:112-24.

Corrales Alexandra, Montoya-G J.V., Sutachan J.J., Cornillez-Ty G., Garavito-Aguilar Z., Xu F., Blanck T.J., Recio-Pinto E.  (2005)  Transient increases in extracellular K+ produce two pharmacological distinct cytosolic Ca2+ transients.  Brain Res.  1031(2):174-84.

Corrales Alexandra, Xu F., Garavito-Aguilar Z.V., Blanck T.J., Recio-Pinto E.  (2004)  Isoflurane reduces the carbachol-evoked Ca2+ influx in neuronal cells.  Anesthesiology.  101(4):895-901.

Garavito-Aguilar Z.V., Recio-Pinto E., Corrales Alexandra V., Zhang J., Blanck T.J., Xu F.  (2004)  Differential thapsigargin-sensitivities and interaction of Ca2+ stores in human SH-SY5Y neuroblastoma cells.  Brain Res.  1011(2):177-86

Newman GC, Delucia-Deranja Evan, Hospod FE.  Arterial to Tissue Transit Times in Middle Cerebral Artery Territories. (Submitted, 2003)

Newman GC, Delucia-Deranja Evan, Tudorica A, Hospod FE, Patlak CS.  Cerebral blood volume measurements by T*2-weighted MRI and contrast infusion. Magn Reson Med. 50:844-55 (2003)

Delucia-Deranja Evan, Patlak CS,  Hospod FE, Tudorica A, Newman GC. Measuring Mean Transit Time in Brain with T2*-MRI Assuming A Homogeneous Capillary Model.  Abstract. Proc. Of Brain ’03 Conference, Calgary Canada, (2003)

DeLucia-Deranja Evan  Cerebral Hemodynamic Measurements with Intravascular Tracers  and T2* Weighted Echo Planar MRI: Comparison of alternative tracer injection and data analysis paradigms. Ph.D. Dissertation.  (2002)

Tudorica A, Li H, Hospod FE, DeLucia-Deranja Evan, Huang W, Patlak, CS, Newman GC.  Cerebral Blood Volume Measurements by Rapid Contrast Infusion and T2*-Weighted Echo Planar MRI. Magn. Reson. Med. 47:1145 (2002)

Kubatzky, KF., Liu, W., Goldgraben, Kerri., Simmerling C., Smith S.O., Constantinescu, S.N.  (2005).  Structural Requirements of the Extracellular to Transmembrane Domain Junction for Erythropoietin Receptor Function J. Biol. Chem., Vol. 280, 14844-14854.

Gravanis, Iordanis and Tsirka, S. E. (2004) tPA and glial function. GLIA 49:177-83.

Hall, Brian E., Yang, S.S., and D. Bar-Sagi  (2002)  Control of Sos activity by intramolecular interactions. Frontiers in Bioscience, 7: D228-D294.

Hall, Brian E., D. Bar-Sagi and N. Nassar.  (2002).  The structural basis for the transition from Ras-GTP to Ras-GDP. Proc. Natl. Acad. Sci. 99: 12138-42.

Iwamoto, Michelle A., Fairclough, S.R., Rudge, S.A., and Engebrecht, J. (2005). Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis. Eukaryot Cell. 4(3):536-44.

Rudge, S.A., Sciorra, V.A., Iwamoto, Michelle A., Zhou, C., Strahl, T., Morris, A.J., Thorner, J., and Engebrecht, J. (2004).  Roses of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.  Mol. Biol. Cell. 15: 207-18

Lu, Weiquan, and Tsirka, S.E. (2002) Partial rescue of neural apoptosis in the lurcher mutant mouse through elimination of tissue plasmonogen activator, Development 129: 2043-2050.

Rogove, Andrew, Lu, Weiquan, and Tsirka, S.E. (2002) Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration. Cell Death Diff 9:801-806.

Lu, Weiquan, Bhasin, M., and Tsirka, S.E. (2002) Involvement of tissue plasminogen activator in both onset and effector phases of experimental allergic encephalomyelitis. J. Neurosci. 22: 10781-10789.

Barbarich-Marsteller NC, Marsteller Douglas A, Alexoff DL, Fowler JS, Dewey SL. (2005) MicroPET imaging in an animal model of anorexia nervosa.  Synapse 57: 85-90.

Marsteller, Douglas A, Barbarich-Marsteller NC, Alexoff DL, Schiffer WK, Dewey SL. (2006) Administration of Corticosterone and Citalopram:  Behavioral Shifts Through Time. Nucl Med Biol. 33(1):71-9.

Gerasimov, M.R., Ferrieri, R., Schiffer, W.K., Marsteller, Douglas, and Dewey, S.L. (2002) Stusy of brain uptake and biodistribution of an abused inhalent using PET and a novel raiotracer ¹¹C-toluene. Life Sciences 70: 2811-2828.

Gerasimov, M.R., Schiffer, W.K., Marsteller, Douglas, Ferrieri, R., Alexoff, D., and Dewey, S.L., (2002) Toluene inhalation produces regionally specific changes in extracellular dopamine. Drug Alcohol Depend 65: 243-251.

Marsteller, Douglas, Gerasimov, M.R., Schiffer, W.K., Geiger, J.M., Barnett, C.R., Schaich Borg, J., Volkow, N.D., Molina, P.E., Alexoff, D.A., and Dewey, S.L. (2002) Acute handling stress modulates methylphenidate induced catecholamine overflow in the medial prefrontal cortex. Neuropsychopharmacology  (In press)

Schiffer WK, Mirrione Martine M, Biegon A, Alexoff DL, Patel V, Dewey SL. (2006) Serial microPET measures of the metabolic reaction to a microdialysis probe implant. J Neurosci Methods. Mar 4; [Epub ahead of print] PMID: 16519945 [PubMed - as supplied by publisher]

Mirrione Martine M, Schiffer WK, Siddiq M, Dewey SL, Tsirka SE. (2006) PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy. Synapse 59(2):119-21.

Schiffer WK, Mirrione, Martine M, Alexoff DL, and Dewey SL. (2003)  Molecular mechanisms of 

pharmacotherapy and treatment efficacy:  Development of an effective treatment strategy for drug 

addiction.  Department of Energy Frontiers in Neuro-Imaging, Boston MA.

Parathath SR, Parathath Saj, Tsirka SE. (2006) Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice. J Cell Sci. 119(Pt 2):339-49  

Parathath, Saj, Sahoo, D., Darlington, Y.F., Peng, Y., Collins, H.L., Rothbalt, G.H., Williams, D.L., and Connelly, M.A.(2004) Glycine 420 Near the C-terminal Transmembrance Domain of SR-BI is Critical for Proper Deliver and Metabolism of HDL-cholesteryl ester. J. Biol. Chem; 279(24):24976-85 

Parathath Saj, Connelly MA, Rieger RA, Klein SM, Abumrad NA, De La Llera-Moya M, Iden CR, Rothblat GH, Williams DL (2004). Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. J. Biol.Chem 279(40):41310-8. 

Peng, Yinan, Akmentin, W., Connelly, M.A., Lund-Katz, S., Phillips, M.C., and Williams, D.L.  (2004)  Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high density lipoprotein.  Mol. Biol. Cell, 15:384-396  

Connelly, M.A., de la Llera-Moya, M., Peng, Yinan, Drazul-Schrader, D., Rothblat, G.H., and Williams D.L. (2003) Separation of Lipid Transport Functions by Mutations in the Extracellular Domain of Scavenger Receptor Class B, Type I.  J. Biol. Chem., 278:25773-25782  

Rogove, Andrew, Lu, Weiquan, and Tsirka, S.E. (2002) Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration. Cell Death and Differentiation 9:801-806.  

Zhao, X., Schramm, Laura, Hernandes, N., and Herr, W. (2003) A Shared surface of TBP Directs RNA Polymerase II and III Transcription via Association with Different TFIIB Family Members.  Molecular Cell 11: 151-161.

Schramm, Laura and Hernandez, L. (2002) Recruitment of RNA Polymerase III to its Target Promoters.  Genes & Dev. 16: 2593-2620.  

K Xanthopoulos, I Paspaltsis, V Apostolidou, S Petrakis, Siao, Chia-Jen, A Kalpatsanidis, N Grigoriadis, A Tsaftaris, SE Tsirka, and T Sklaviadis T (2005) Tissue plasminogen activator in brain tissues infected with transmissible spongiform encephalopathies. Neurobiol Dis, 20: 519-27.  

Siao, Chia-Jen, Fernandez, S.R. and Tsirka, S.E., (2003) Rapid onset on neuronal death in mice expressing tissue plasminogen activator on microglia, J Neurosci. 23: 3234-3242  

Siao, Chia-Jen, and Tsirka, S.E. (2002) Extracellular proteases and neuronal cell death. Mol. Cell. Biol., 48: 151-161  

Spinner, Daryl S., Liu, S., Wang, S-W., and Schmidt, J. (2002) Interaction of the Myogenic Determination Factor Myogenin with E12 and a DNA Target: Mechanism and Kinetics. J. Mol. Biol. 317: 431-445.  

Okur, A., Strockbine, Bentley, Hornak, V., and Simmerling, C. (2003) Using PC clusters to evaluate the transferability of molecular mechanics force fields for proteins.  J. Computational Chem. 12: 21-31.

Simmerling, C., Strockbine, Bentley, and Roitberg, A.E. (2002) All-atom structure prediction and folding simulations of a stable protein. J  Am Chem. Soc. 124: 11258-11259

Su, Wenjuan, Chardin, P, Yamazaki, M, Kanaho, Y and Du, G (2006) RhoA-mediated Phospholipase D1 signaling is not required for the formation of stress fibers and focal adhesions. Cellular Signaling, 18: 469-478

Bogenhagen DF, Wang, Yousong, Shen EL, Kobayashi R.  (2003).  Protein components of mitochondrial DNA nucleoids in higher eukaryotes. Mol Cell Proteomics. 11:1205-16. Epub 2003 Sep 26.

Washburn RS, Wang, Yousong, Gottesman ME.  (2003).  Role of E.coli transcription-repair coupling factor Mfd in Nun-mediated transcription termination.J. Mol Biol. 13:655-62.

Weston, Christi, Gordon, C., Teressa, G., Hod, E., Ren, X.D., and Prives, J. (2003) Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cells.  J Biol Chem. 278:6450-6455.

Zhang, Yan, Huang, P,Du, G, Kanaho, Y, Frohman, M and Tsirka, SE (2004) Increased expression of two Phospholipase D isoforms during hippocampal mossy fiber outgrowth. GLIA, 46:74-83.

Zhang, Yan, Kanaho, Y. Frohman, M, and Tsirka SE (2005) Regulated Secretion of Tissue Plasminogen Activator During Neurite Outgrowth. J. Neurosci 25, 1797-1805.

Zhang, Yan, Pothakos K, and Tsirka, SE (2005) Extracellular proteases –biological and behavioral roles in the mammalian CNS. Current Topics in Developmental Biology 66, 161-188.

CONFERENCES / COLLOQUIA / PRESENTATIONS / SYMPOSIUMS / WORKSHOPS  

Caces, Donne Bennett  (2003) The American Society for Cell Biology, 43^rd Annual Meeting. San Francisco, CA, December 13–17.  

Caces, Donne Bennett. (2005) Adipocytes support cAMP-dependent translocation of Aquaporin 2 (AQP2) from intracellular sites distinct from the insulin-responsive GLUT4 storage compartment. 4th International Conference on Aquaporins. Brussels, Belgium.  

Connolly, Jaime E., Rudge, S.A., and Engebrecht, J. (2002) “Differential Role of Phosphoinositide Transfer Protein, Sec14, in Vegatative Cells and Sporulation,” presented at the Yeast Genetics and Molecular Biology Meeting, Madison, Wisconsin, July 30-August 4.  

Connolly, Jaime E., and Engebrecht, J. (2003). Functional Analysis of Arf-GAPs in Sporulation. Presented at the 2003 Retreat at Fallen Leaf Lake, South Lake Tahoe, California, October 10-12. (University of California, Davis, CA)

Connolly, Jaime E., and Engebrecht, J. (2004). Functional Analysis of Gcs1 in Sporulation, presented at The 2004 Yeast Genetics and Molecular Biology Meeting, University of Washington, Seattle, Washington, July 27-August 1. 

Connolly, Jaime E., and Engebrecht, J. (2004). Functional Analysis of Gcs1p in Sporulation.  Presented at the 2004 Retreat at Fallen Leaf Lake, South Lake Tahoe, California, October 8-10. (University of California, Davis, California)  

Connolly, Jaime E., and Engebrecht, J. (2005). Closing the GAP: Relationship between PLD and Arf-GAPs in Sporulation. to be presented at the 2005 Yeast Cell Biology Meeting, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, August 16-21.  

Sutachan J.J., Corrales Alexandra, Xu F., Blanck Thomas J.J., Recio-Pinto, E.  (2004)  Effect of Pluronic Acid on Fura-2-Trace KCl-Evoked Transient Increase in Cytoplasmic Ca2+ in the Absence and Presence of Isoflurane.  American Society of Anesthesiologists Annual Meeting, Las Vegas, NV. 

Corrales-Higuera, Alexandra, Xu, F., Comillez-Ty, G., Blanck Thomas, JJ., and Recio Pinto, E. (2003).  Pulses of KCl produce two cytosolic Ca²⁺ transients one upon initiation of the KCl pulse that is isoflurane-sensitive and the second one upon removal of KCl that is isflurane-insensitive, presented at the ASA Annual Meeting, San Francisco, California,  

Corrales-Higuera, Alexandra, Xu, F., Garavito-Aguilar, Z., Blanck Thomas, JJ., and Recio Pinto, E. (2003).  Isoflurane action on the carbachol-evoked cytosolic Ca²⁺ transients is dependent on extracellular Ca²⁺, presented at the ASA Annual Meeting, San Francisco-California,  

DeLucia-Deranja, Evan, Tudorica, A. Patlak, C., Li, H., Hospod, F, and Newman, G. (2000) "Novel Method for Measuring Absolute Cerebral Mean Transit Time (MTT) with Perfusion MRI", presented at The 30th Annual Meeting of Neuroscience, November 4-9, New Orleans, LA.  

Feigin, Michael, Wang, H-Y, Malbon, CC (2006). RGS protein regulation of Wnt/β-catenin signaling. Keystone Symposium on Wnt and beta-Catenin Signaling, Snowbird, UT  

Gravanis, Iordanis, Hajjar, K.A., and Tsirka, S.E. (2005) tPA-dependent annexin A2-mediated microglial activation. presented at the 10^th International Workshop on the Molecular &Cellular Biology of Plasminogen Activation, Washington, DC  

Gravanis, Iordanis, Hajjar, K.A., and Tsirka, S.E. (2004) Insights into tPA-dependent annexin A2-mediated microglial activation, presented at the 34^th Annual Meeting of the Society for Neuroscience. San Diego, CA.  

Gravanis, Iordanis, Hajjar, K.A., and Tsirka, S.E. (2004) Insights into tPA-dependent annexin II-mediated microglial Activation, presented at the Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis. Ventura, CA.  

Gravanis, Iordanis, and S.E. Tsirka. (2003) tPA-Mediated Microglial Activation. Seminars of the Laboratory of Biological Chemistry. University of Ioannina Medical School, Ioannina, Greece.  

Pothakos, K., Iordanis Gravanis., J.K. Robinson and S.E. Tsirka. (2003) Effects of Tissue Plasminogen Activator (tPA) in Hippocampus Related Learning and Memory. 33^rd Annual Meeting of the Society for Neuroscience. New Orleans, LA.  

Gravanis, Iordanis, W. Lu, and S.E. Tsirka. (2003) Microglial Activation is Essential for Excitotoxin-Induced, tPA-mediated Neurodegeneration and It Proceeds Via a tPA-Annexin II Interaction. 33^rd Annual Meeting of the Society for Neuroscience. New Orleans, LA.   

Barbarich-Marsteller NC, Marsteller Douglas A, Dewey SL.  (2005).  Effects of long term food deprivation on neuronal activity assessed with 2-deoxy-2-[¹⁸F]fluoro-D-glucose and microPET:  An animal model of anorexia nervosa.  The Academy for Eating Disorders Internation Conference, Montreal, Canada.  

Marsteller Douglas A, Barbarich NC, Schiffer WK, Alexoff DL, Patel VD, Dewey SL.  (2004).  Acute and subacute administration of corticosterone and/or citalopram:  behavioral shifts though time.  Society for Neuroscience 34^th Annual Meeting, San Diego, CA.  

Marsteller Douglas A, Alexoff DL, Barbarich NC, Schiffer WK, Patel V, Dewey SL.  (2004)  Acute &/or Weekly Coricosternone Treatment Alters the Response of 2-Deoxy-2-[¹⁸F]fluoro-D-glucose Accumulation in the Brain.  2004 Neuroendocrine Workshop:  Neuroendocrinology of Energy Balance & Obesity.

Barbarich NC, Marsteller Douglas A, Alexoff DL, Schiffer WK, Dewey SL.  (2004)  Reproducibility of 2-[¹⁸F]-fluoro-2-deoxy-d-glucose uptake with micropet in the awake rat.   Society for Neuroscience 34^th Annual Meeting, San Diego, CA.

Marsteller Douglas.  (2004).  2004 Neuroendocrine Workshop:  Neuroendocrinology of Energy Balance & Obesity, New Orleans, LA.

Schiffer, W.K., Marsteller, Douglas, Gerasimov, M.R., Carter, P., King, P., Shea, C., Logan, J., Alexoff, D.L., and Dewey, S.L. (2002) “Functional Alterations in GABAergic or glutamatergic modulation of dopamine (DA) by chronic neuroleptic treatment: Positron emission tomography (PET) studies in healthy primates”, presented at the Society for Nuclear medicine 49^th Annual Meeting. Los Angeles, CA.

Schiffer, W.K., Marsteller, Douglas, Gerasimov, M.R., Alexoff, D.L., Logan, J., Brodie, J.D., and Dewey, S.L. (2002) “Prolonged neuroleptic exposure differentially alters the endogenous regulation of dopamine (DA): Serial ¹¹C-raclopride PET studeies of GABAergic and glutamatergic modulation of DA in primates treated with clozapine or haloperidol”, presented at the Neuroreceptor Mapping Conference. Oxford, England.

Mirrione, Martine, Schiffer, W.K., Siddiq, M., Dewey, S.L., and Tsirka, S.E. (2005).  Interactions between tPA and Zinc Modulate Seizure Severity during Temporal Lobe Epilepsy, presented at the Xth International Workshop on Molecular and Cellular Biology of Plasminogen Activation, Washington, D.C., April 9-13.  

Mirrione, Martine, Siddiq, M., Schiffer, W.K., Dewey, S.L., and Tsirka, S.E. (2004).  Investigation of the role of tPA and zince in a mouse model of temporal lobe epilepsy, presented at The Society for Neuroscience  34^th Annual Meeting, San Diego, CA, October 23-27.

Siddiq M, Mirrione, Martine M, and Tsirka SE. (2003)  Modulatory roles of zinc and tissue 

plasminogen activator during seizure induction.  Society for Neuroscience 33rd Annual Meeting.

New Orleans, LA. 

Mirrione, Martine M, Schiffer WK, Logan J, Tsirka SE, and Dewey SL.  (2003). “MicroPET imaging of neuronal activation to investigate interactions between zinc and tPA in a mouse model of temporal lobe epilepsy,” presented at The American College of Neuropsychopharmacology, San Juan, Puerto Rico,   December 7-11.  

Ocampo, Christopher  (2003) Factors that Contribute to Sustained Hypergamma-globulinemia in Chronically HIV-Infected Individuals on HAART, presented at The American Society for Microbiology 103^rd Annual Meeting, Washington, D.C., May 18-23.

Ocampo, Christopher.  (2003) “Sustained T Cell Responses in HIV-Infected Patients on Stable HAART with Five Years of Undetectable Serum Viral Load”, presented at the AIDS Vaccine 2003 Meeting, New York, NY, September 19.  

Parathath, Saj, RA Rieger, MA Connelly, CR Iden and DL Williams. (2004) AlteredPhosphatidylcholine Subspecies Distribution in Scavenger Receptor- Expressing Cells May Contribute to Lipid Transport Functions Gordon Conference 2004 Lipoprotein Metabolism, Meriden, NH, June 13-18.

Connelly MA, Parathath Saj, D Sahoo , Y F. Darlington , Yinan Peng , HL. Collins , GH Rothblat and DL Williams. (2004) 420 near the c-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of HDL cholesteryl ester Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology  San Francisco, CA

Parathath, Sajesh.  (2003).  American Heart Association Scientific Sessions .  

Parathath, Sajesh.  (2004) American Heart Association Scientific Sessions.

Parathath, Sajesh.  (2003) The 4^th Annual Conference on Atherosclerosis, Thrombosis and Vascular Biology, Washington, DC, May 8-10..  

Peng, Yinan, Akmentin, W., Lund-Katz, S., Phillips, M., and Williams, D.L. (2002). “Analysis of Scavenger Receptor Class B, Type 1 (SR-BI) Localization and Its Association with Membrane Microdomains,” presented at The Gordon Research Conferences Lipoprotein Metabolism, Meridan, NH, June 16-21.  

Peng, Yinan and Williams, D.L. (2002) “Analysis of Scavenger Receptor Class B, Type 1 (SR-BI) Localization and Its Association With Membrane Microdomains,” presented at The American Heart Association 75th Annual Scientific Sessions, Chicago, IL.  Circulation 106(19): II-77.  

Peng, Yinan.  (2003). The 4^th Annual Conference on Atherosclerosis, Thrombosis and Vascular Biology, Washington, DC, May 8-10..  

Peng, Yinan. (2003). The American Heart Association 76th Annual Scientific Sessions, Orlando, FL, November 8-11.  

Connelly M.A., Parathath S., Sahoo D., Darlington Y.F., Peng Yinan, Collins H.L., Rothblat G.H. and Williams D.L. (2004). Glycine 420 near the c-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of HDL cholesteryl ester, presented at The 5^th Annual Conference on  Atherosclerosis Thrombosis Vascular Biology, San Francisco, CA, May 6-8. ATVB. 24(5):e51.   

Pfaffly, Jennifer R., Engle, M., Backer, J.M., Pirola, L., van Obberghen, E., Pessin, J.E.  (2002) “GLUT4 Targeting to Insulin-Responsive Compartment in 3T3-L1 Adipocytes Is Inhibited by the Lipid Phosphatase Myotubularin”, presented at the American Diabetes Association 62^nd Annual Meeting and Scientific Sessions, San Francisco.  

Pfaffly, Jennifer R. Engle, M., Backer, J.M., Pirola, L., van Obberghen, E., Pessin, J.E. (2002) “Myotubularin inhibits the targeting of GLUT4 to insulin-specific compartments.”, presented at the 42^nd American Society for Cell Biology Annual Meeting, San Francisco, CA, December 14–18.  

Pfaffly, Jennifer R.  (2003)  American Society of Cell Biology, 43^rd Annual Meeting.  San Francisco, CA, December 13–17.  

Pfaffly, Jennifer R.  (2003) FASEB Summer Research Conference “Glucose Transporter Biology”, Snowmass, CO, August.  

Sawey, Eric (2004) International Meeting on Inhibition of Matrix Metalloproteinases: Therapeutic Applications, New York, NY, October.  

Sheehan John.J. (Jack), Rogove Andrew.D., Zhou C., and Tsirka S.E. (2005) Recruitment of Microglia by Plasmin-Mediated Cleavage of Monocyte Chemoattractant Protein-1 is Necessary for Progression of Excitotoxin-Induced Cell Death in the Adult Mouse Hippocampus. Presented at Experimental Biology 2005, San Diego, CA; abstract LB350.                                                  

Sheehan, John and Tsirka, S. (2002) “Reduction Of Microglia Cell Populations Before Induction Of Excitotoxicity Reduces Neurodegeneration,” presented at The Society for Neuroscience’s 32^nd Annual Meeting, Orlando, FL, November 2-7.  

Sheehan, John (2002) Student participant at the Biochemical Topical Group - New York Academy of Science Joint Conference, “The Role of Microglia in Neurodegeneration”  New York, NY, April 23, 2002.  

Sheehan, John, Rogove, A.; Wu, Y. and Tsirka, S.  (2003)  “Plasmin Mediated Cleavage of Monocyte Chemoattractant Protein Directs Migration of Microglia to Sites of Injury in the Adult Mouse Hippocampus Resulting in Excitotoxin-Induced Cell Death.  Euroglia.  Berlin, Germany. September 3-6.  

Sheehan, John, Rogove, A.D., Wu.Y, Tsirka, S.E.  (2003)   “Excitotoxin-Induced Cell Death in the Adult Mouse Hippocampus Involves Plasmin-Mediated Cleavage of Monocyte Chemoattractant Protein to Properly Target Microglia to the Injury Site.”  Neuroscience.  New Orleans, LA.  November 8-12.  

Song, Yan (2004) International Meeting on Inhibition of Matrix Metalloproteinases: Therapeutic Applications, New York, NY, October.  

Su, Wenjuan, Zhang, Y. Kanaho, Y. Bliska, J. and Frohman, MA (2006) Role of PI4P5Kinase-alpha in phagocytosis. Tskuba University, Tokyo, Japan.  

Weston, C., Gordon, C., Teressa, G., Scotto-Lavino, E., Weeks, B., and Prives, J. (2002). “Rac and rho cooperatively mediate agrin - induced acetylcholine receptor clustering,” presented at The 42^nd American Society for Cell Biology Meeting, San Francisco, CA, December 14-18.  

Weston, Christi., Teressa, G., Gordon, C., Zarefes, S., and Prives, J. (2003). Localization of agrin-induced acetylcholine receptor clustering is directed by Rac and Rho. 43^rd American Society for Cell Biology Meeting, San Francisco, CA, December 13 – 17.  

Zhang, Yan, et al.  (2003) “Regulation of Tissue Plasminogen Activator Secretion During Neurite Outgrowth”, presented at the 33^rd annual meeting of the Society for Neuroscience.  New Orleans, LA.  

POST-DOCTORAL POSITIONS OBTAINED

2002-2006

Baniecki, Mary Lynn (Ph.D., 2003)  Post-doctoral position, Dr. Jon Clardy, P.I., Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Cambridge, MA

Brown, Mark (Ph.D., 2002)  Post-doctoral Fellow, Dr. Patricia Johnson, Dept. of Microbiology, UCLA, Los Angeles, CA.

Connolly-Rohrbach, Jamie (Ph.D. 2005) Post-doctoral Fellow, Molecular and Cellular Biology, University of California at Davis, Davis, CA

DeLucia-Deranja, Evan  (Ph.D., 2002; M.D., 2004) Resident in Psychiatry, SUNY Upstate Medical University, Syracuse, NY.

Emran, Farida (Ph.D., 2004) Post-doctoral position, Dr. John Dowling, Molecular and Cellular Biology, Harvard University, Cambridge, MA.

Hall, Brian (Ph.D., 2002) Post-doctoral position, Dr. Tom Ellenberger, Biochemistry and Molecular Pharmacology, Harvard Medical School,  Cambridge, MA.  

Iwamoto, Michelle (Ph.D., 2003) Scientific Consultant, Frommer Lawrence and Haug, LLC., New York, NY.  

Liu, Nancy (Yang) (Ph.D., 2006) Post-doctoral Fellow. Dr. Scott Powers, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY .

Lu, Weiquan (Ph.D., 2006) Post-doctoral Fellow, Dr. L Chang, Medical Department, Brookhaven National Laboratory, Upton, NY.  (2005) Resident in Anesthesiology, Drexel University Medical Center, Philadelphia, PA.