Faculty / Research
Arthur P. Grollman, MDDistinguished Professor
Evelyn G. Glick Professor of Experimental Medicine
Director: Laboratory for Chemical Biology
M.D., Johns Hopkins University School of Medicine
Molecular Carcinogenesis: Mechanisms of DNA Repair and Mutagenesis in Mammalian Cells
Research in the Laboratory of Chemical Biology (LCB), for which Dr Grollman serves as Director, focuses on the biological consequences of DNA damage with specific reference to molecular mechanisms of DNA replication, mutagenesis, and DNA repair. Research in the LCB was instrumental in establishing the mechanism of action of bleomycin and in defining an important error-avoidance pathway that protects cells against mutations resulting from miscoding effects of oxidative DNA damage. He and his collaborators established the three-dimensional structures of DNA glycosylases and DNA polymerases bound to site-specifically modified DNA, thereby correlating the molecular structure of damaged DNA with enzymatic function. Current research focuses on molecular and cellular mechanisms involved in the nephrotoxicity of the human carcinogen, aristolochic acid.
- Catalytic mechanism of Escherichia coli endonuclease VIII: Roles of the intercalation loop and the zinc finger. Kropachev K.Y., Zharkov D.O., Grollman A.P. Biochemistry 45, 12039-49 (2006)
- Computational analysis of the binding mode of 8-oxoguanine to formamidopyrimidine-DNA glycosylase. Song K, Hornak V, de los Santos C, Grollman AP, Simmerling C. Biochemistry 45 (36), 10886-94 (2006)
- Aristolochic acid and the etiology of (Balkan) endemic nephropathy. Grollman AP, Shibutani S, Moriya M , Miller F, Wu L, Moll U, Suzuki N, Fernandes A, Medverec Z, Jakovina K, Brdar B, Slade N, Rieger R, Vukelic M, Jelakovic B. Proc Natl Acad Sci USA. 104(29): 12129-34 (2007)
- Molecular simulations reveal a common binding mode for glycosylase binding of oxidatively damaged DNA lesions. Song K, Kelso C, de los Santos C, Grollman AP, Simmerling C. J Am Chem Soc. 129(47): 14536-7 (2007)
- Aristolochic Acid Nephropathy: An Environmental and Iatrogenic Disease. Grollman AP, Scarborough J, Jelakovic´ B. Advances in Molecular Toxicology, 3. Ed. Fishbein JC. Elsevier: Amsterdam, The Netherlands, 2009. 211-222.