SUNY Stony Brook
Selected Publications
Guainazzi A, Campbell AJ, Angelov T, Simmerling C, Schärer OD (2009) A stable and isostructural synthetic mimic of a nitrogen mustard DNA interstrand crosslink. Submitted
Ahmad A, Enzlin JH, Wijgers N, Raams A, Appledorn E, Theil AE, Hoeijmakers JHJ, Vermeulen V, Jaspers NGJ, Schärer OD*, Niedernhofer LJ* (2009) Aberrant sub-cellular localization of DNA repair protein XPF: the molecular basis for extracutaneous symptoms in xeroderma pigmentosum. PLoS Genet, in revision. *Co-corresponding authors
Orelli B, McClendon BT, Tsodikov, OV, Ellenberger T, Niedernhofer LJ, Schärer OD (2009) The interaction between ERCC1 and XPA is required for nucleotide excision repair, but not other DNA repair pathways. J Biol Chem, published on November 23, 2009, DOI: M109.067538
Knipscheer P, Räschle M, Smorgorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC (2009) The Fanconi anemia pathway promotes replication-dependent DNA interstrand crosslink repair. Science 326, 1698-1691.
Schärer OD (2009) Structure-specific endonucleases in DNA repair. (Invited review for special issue - Swiss Chemists in the USA) Chimia, 63, 753-757.
Staresincic L, Fagbemi AF, Enzlin JH, Gourdin AM, Wijgers N, Dunand-Sauthier I, Giglia-Mari G, Clarkson SG, Vermeulen W, Schärer OD (2009) Coordination of dual incision and repair synthesis in human nucleotide excision repair. EMBO J 28, 1111-1120.
Schärer OD, Campbell AJ (2009) Wedging out DNA damage (News & Views article). Nat Struct Mol Biol 16, 102-104.
Angelov T, Guainazzi A, Schärer OD (2009) Generation of DNA interstrand crosslinks by postsynthetic reductive amination. Org Lett 11, 611-614.
Räschle M, Knipsheer P, Enoiu M, Angelov T, Sun J, Griffith JD, Ellenberger T, Schärer OD, Walter JC (2008) Mechanism of replication-coupled DNA interstrand cross-link repair. Cell, 134, 969-908.
Schärer, O.D. (2008) Molecular basis for different disease states caused by mutations in TFIIH and XPG (Hot topics in DNA repair). DNA Repair 7, 339-344 (2008)
Schärer, O.D. (2008) A molecular basis for damage recognition in eukaryotic nucleotide excision repair (Highlight). ChemBioChem 9, 21-23
Tsodikov, O.V., Ivanov, D., Orelli, B., Staresincic, L., Shoshani, I., Schärer, O.D., Wagner, G., Ellenberger, T. (2007) Structural basis for recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA . EMBO J26, 4768-4776
Schärer, O.D. (2007) XPG: it's product and biological roles. In Molcular Mechanisms of Xeroderma Pigmentosum (Ahmed, S.I. and Hanaoka, F., eds) Landes Biosciences
Schärer, O.D. (2007) Achieving broad substrate specificity in damage recognition by binding exposed non-damaged DNA (Preview). Mol Cell 28, 184-186
Hohl, M., Dunand-Sauthier, I., Staresincic, L., Jaquier-Gubler, P., Thorel, F., Modesti, M., Clarkson, S.G., Schärer, O.D. (2007) Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity. Nucleic Acids Res 35, 3053-63
Alzeer, J.C. and Schärer, O.D. (2006) A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks. Nucleic Acids Res 35, 4458-66
Gillet, L.C. and Schärer, O.D. (2006) Molecular mechanisms of mammalian global genome nucleotide excision repair (Invited Review). Chem Rev 106, 253-76
Tsodikov, O.V., Enzlin, J.H., Schärer, O.D., Ellenberger, T. (2005) Crystal structure and DNA binding functions of ERCC1, asubunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc Natl Acad Sci U S A 102, 11236-41
Gillet, L.C., Alzeer, J., Schärer, O.D. (2005) Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified 'ultra-mild' DNA synthesis. Nucleic Acids Res 33, 1961-9
Schärer, O.D. (2005) DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses (Review). Chembiochem 6, 27-32
Schärer, O.D. and Schultz, C. (2005) Closing the gap between chemistry and biology (Editorial). Chembiochem 6, 3-5
Dunand-Sauthier, I., Hohl, M., Thorel, F., Jaquier-Gubler P., Clarkson, S.G., Schärer, O.D. (2005) J Biol Chem 280, 7030-7
Tapias, A., Auriol, J., Forget, D., Enzlin, J.H., Schärer, O.D., Coin, F., Coulombe, B., Egly, J.M. (2004) Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors. J Biol Chem 279, 19074-83
Schärer, O.D. (2003) Chemistry and biology of DNA repair (Invited Review). Angew Chem Int Ed Engl 42, 2946-74
Hohl, M., Thorel, F., Clarkson, S.G., Schärer, O.D. (2003) Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG. J Biol Chem 278, 19500-8
Gillet, L.C. and Schärer, O.D. (2002) Preparation of C8-amine and acetylamine adducts of 2'-deoxyguanosine suitably protected for DNA synthesis. Org Lett 4, 4205-8
Enzlin, J.H. and Schärer, O.D. (2002) The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif. EMBO J 21, 2045-53