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| Selected Publications |
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Angelov T, Guainazzi A, Schärer OD (2008) Generation of DNA interstrand crosslinks by postsynthetic reductive amination. (submitted) |
Pubmed |
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Staresincic L, Enzlin JH, Gourdin AM, Wijgers N, Dunand-Sauthier I, Giglia-Mari G, Clarkson SG, Vermeulen W, Schärer OD (2008) Coordination of dual incision and repair synthesis in human nucleotide excision repair. (submitted)
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Pubmed |
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Räschle M, Knipsheer P, Enoiu M, Angelov T, Sun J, Griffith JD, Ellenberger T, Schärer OD, Walter JC (2008) Mechanism of replication-coupled DNA interstrand cross-link repair. Cell, 134, 969-908. |
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Schärer, O.D. (2008) Molecular basis for different disease states caused by mutations in TFIIH and XPG (Hot topics in DNA repair). DNA Repair 7, 339-344 (2008)
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Schärer, O.D. (2008) A molecular basis for damage recognition in eukaryotic nucleotide excision repair (Highlight). ChemBioChem 9, 21-23
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Tsodikov, O.V., Ivanov, D., Orelli, B., Staresincic, L., Shoshani, I., Schärer, O.D., Wagner, G., Ellenberger, T. (2007) Structural basis for recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA . EMBO J26, 4768-4776
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Schärer, O.D. (2007) XPG: it's product and biological roles. In Molcular Mechanisms of Xeroderma Pigmentosum (Ahmed, S.I. and Hanaoka, F., eds) Landes Biosciences
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Schärer, O.D. (2007) Achieving broad substrate specificity in damage recognition by binding exposed non-damaged DNA (Preview). Mol Cell 28, 184-186 |
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Hohl, M., Dunand-Sauthier, I., Staresincic, L., Jaquier-Gubler, P., Thorel, F., Modesti, M., Clarkson, S.G., Schärer, O.D. (2007) Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity. Nucleic Acids Res 35, 3053-63 |
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Alzeer, J.C. and Schärer, O.D. (2006) A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks. Nucleic Acids Res 35, 4458-66 |
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Gillet, L.C. and Schärer, O.D. (2006) Molecular mechanisms of mammalian global genome nucleotide excision repair (Invited Review). Chem Rev 106, 253-76 |
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Tsodikov, O.V., Enzlin, J.H., Schärer, O.D., Ellenberger, T. (2005) Crystal structure and DNA binding functions of ERCC1, asubunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc Natl Acad Sci U S A 102, 11236-41 |
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Gillet, L.C., Alzeer, J., Schärer, O.D. (2005) Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified 'ultra-mild' DNA synthesis. Nucleic Acids Res 33, 1961-9 |
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Schärer, O.D. (2005) DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses (Review). Chembiochem 6, 27-32 |
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Schärer, O.D. and Schultz, C. (2005) Closing the gap between chemistry and biology (Editorial). Chembiochem 6, 3-5 |
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Dunand-Sauthier, I., Hohl, M., Thorel, F., Jaquier-Gubler P., Clarkson, S.G., Schärer, O.D. (2005) J Biol Chem 280, 7030-7 |
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Tapias, A., Auriol, J., Forget, D., Enzlin, J.H., Schärer, O.D., Coin, F., Coulombe, B., Egly, J.M. (2004) Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors. J Biol Chem 279, 19074-83 |
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Schärer, O.D. (2003) Chemistry and biology of DNA repair (Invited Review). Angew Chem Int Ed Engl 42, 2946-74 |
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Hohl, M., Thorel, F., Clarkson, S.G., Schärer, O.D. (2003) Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG. J Biol Chem 278, 19500-8 |
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Gillet, L.C. and Schärer, O.D. (2002) Preparation of C8-amine and acetylamine adducts of 2'-deoxyguanosine suitably protected for DNA synthesis. Org Lett 4, 4205-8 |
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Enzlin, J.H. and Schärer, O.D. (2002) The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif. EMBO J 21, 2045-53 |
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