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Feng-Qian Li, Ph.D. –Assistant Professor of Research

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Assistant Professor of Research
Pharmacological Sciences

Dept. of Pharmacology BST 7-186/183
Stony Brook, NY 11794-8651
Phone: (631) 444-8887
Fax: (631) 444-3218
E-mail: li@pharm.stonybrook.edu

Ph.D., Graduate University for Advanced Studies, Japan
Postdoctoral, Dept. of Medicine, University of Washington
We are interested in many aspects of developmental, cellular and molecular biology. Correctly, we focus on studying the function of signaling regulators involved in cell growth regulation, cancer biology and adipogenesis. One of the major interests in the laboratory is to decipher cellular and molecular mechanisms by which Chibby, the antagonist of β-catenin, modulates signal transduction pathways, particularly, the Wnt/β-catenin pathway, thereby effects expression of downstream target genes and influences cellular events. Our exciting projects involve the analysis of intracellular signaling pathways using conditional gene knockout (Cre-LoxP) approach in mice, and are complimented with in vitro cell culture and biochemical analysis.

Research Opportunities
Please contact Feng-Qian Li at li@pharm.stonybrook.edu or 631-444-8887 for information regarding the availability of post-doctoral, graduate and undergraduate positions.

Selected Publications

Adaobi Mofunanya, Feng-Qian Li, Jen-Chih Hsieh & Ken-Ichi Takemaru (May 2009). Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif. BMC Biology., in press.

Voronina A. Voronina, Ken-Ichi Takemaru, Piper Treuting, Damon Love, Barbare R. Grubb, Adeline M. Hajjar, Allison Adams, Feng-Qian Li & Randall T. Moon (Apr. 2009). Inactivaton of Chibby affects function of motile airway cilia. J. Cell Biol., 185:225-233.

Ken-Ichi Takemaru, Victoria Fischer & Feng-Qian Li (Jan. 2009). Fine-tuning of nuclear β-catenin by Chibby and 14-3-3. Cell Cycle, 8: 210-213 (Review).

*Feng-Qian Li, Adaobi Mofunanya, Kimberley Harris & *Ken-Ichi Takemaru (Jun. 2008). Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity. J. Cell Biol., 181:1141-1154. *Co-correspondence.

This research article was selected for:
Wink A) Research Highlights in Nature Reviews-Molecular Cell Biology (Aug. 2008)- Cell signalling: AKTing in Wnt pathway by Ekat Kritikou.
Wink B) Selected Updates in Nature Signaling Gateway (Aug. 2008)-AKTing in Wnt pathway.
Wink C) Faculty of 1000 Biology (Sep. 2008)-Major Advances, Expert Opinions by Frans Van Roy.
 

Ken-Ichi Takemaru, Masao Ohmitsu & Feng-Qian Li (Feb. 2008). An oncogenic hub: β-catenin as a molecular target for cancer therapeutics. Handbook Exp. Pharmacol., 186: 261-284.

Feng-Qian Li, Amar Singh, Adaobi Mofunanya, Damon Love, Naohiro Terada, Randall T. Moon & Ken-Ichi Takemaru (Jun. 2007). Chibby promotes adipocyte differentiation through inhibition of β-catenin signaling. Mol. Cell Biol., 27 (12): 4347-4354.

Amar M. Singh, Feng-Qian Li, Takashi Hamazaki, Hideko Kasahara, Ken-Ichi Takemaru & Naohiro Terada (Feb. 2007). Chibby, an antagonist of the Wnt/β-catenin pathway, facilitate cardiomyocyte differentiation of murine embryonic stem cells. Circulation. 115(5): 617-626.

Kathleen F. Benson, Richard E. Person, Feng-Qian Li, Kayleen Williams & Marshall Horwitz (Dec. 2004). Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia. Nucleic. Acids. Res. 32(21): 6327-6333.

Marshall Horwitz, Kathleen F. Benson, Zhijun Duan, Feng-Qian Li & Richard E. Person (Apr. 2004). Hereditary neutropenia: dogs explain human neutrophil elastase mutations. Trends Mol. Med. 10 (4): 163-170 (Review).

Feng-Qian Li, Richard E. Person, Ken-Ichi Takemaru, Kayleen Williams, Kimberly Meade-White, Ayse H. Ozsahin, Tayfun Gungor, Randall T Moon & Marshall Horwitz (Jan. 2004). Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binging factor a regulation of ELA2. J. Biol. Chem., 279 (4): 2873-2884.

Zhijun Duan, Feng-Qian Li, Jeremy Wechsler, Kimberly Meade-White, Kayleen Williams, Kathleen F. Benson & Marshall Horwitz (Jan. 2004). A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia. Mol. Cell Biol., 24 (1): 58-70.

Kathleen F. Benson, Feng-Qian Li, Richard E. Person, Dalila Albani, Zhijun Duan, Jeremy Wechsler, Kimberly Meade-White, Kayleen Williams, Gregory M. Acland, Glenn Niemeyer, Clinton D. Lothrop & Marshall Horwitz (Sep. 2003). Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat. Genet, 35(1): 90-96.

*Richard E. Person, * Feng-Qian Li, * Zhijun Duan, Kathleen F. Benson, Jeremy Wechsler, Helen A. Papadaki, George Eliopoulos, Christina Kaufman, Salvatore J. bertolone, Betty Nakamoto, Thalia Papayannopoulou, H. Leighton Grimes & Marshall Horwitz (Jul. 2003). Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat. Genet, 34(3): 308-312. * Contributed equally.

Marshall Horwitz, Feng-Qian Li, Dalila Albani, Zhijun Duan, Richard E. Person, Kimberly Meade-White & Kathleen F. Benson (Jul. 2003). Leukemia in severe congenital neutropenia: defective proteolysis suggests new pathways to malignancy and opportunities for therapy. Cancer Invest., 21(4): 579-587 (Review).

Marshall Horwitz, Kathleen F. Benson, Zhijun Duan, Richard E. Person, Jeremy Wechsler, Kayleen Williams, Dalila Albani & Feng-Qian Li (Jan. 2003). Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone' hypothesis. Curr. Opin. Hematol., 10 (1): 49-54. (Review).

Feng-Qian Li & Marshall Horwitz (Apr. 2001). Characterization of mutant neutrophil elastase in severe congenital neutropenia. J. Biol. Chem., 276 (17): 14230-14241.

Feng-Qian Li, Archie Coonrod & Marshall Horwitz (Jul. 2000). Selection of a dominant negative retinoblastoma protein (RB) inhibiting satellite myoblast differentiation implies an interaction between MyoD and RB. Mol. Cell Biol., 20 (14): 5129-5139.

Archie Coonrod, Feng-Qian Li & Marshall Horwitz (Dec. 1997). On the mechanism of DNA transfection: efficient gene transfer without viruses. Gene Therapy, 4 (12): 1313-1321.

Marshall Horwitz, Kathleen F. Benson, Feng-Qian Li, John Wolff, Mark F. Leppert, Lynne Hobson, Marie Mngelsdorf, Sui Yu, Duncan Hewett, Robert I. Richards & Wendy H. Raskind (Oct. 1997). Genetic heterogeneity in familial acute myelogenous leukemia: evidence for a second locus at chromosome 16q21-23.2. Am. J. of Human Genet., 61 (4): 873-881.

Ken-Ichi Takemaru, Feng-Qian Li, Hitoshi Ueda & Susumu Hirose (Jul. 1997). Multiprotein bridging factor 1 (MBF1) is an evolutionarily conserved transcriptional coactivator that connects a regulatory factor and TATA element-binding protein. Proc. Natl. Acad. Sci. USA, 94 (14): 7251-7256.

Feng-Qian Li, Ken-Ichi Takemaru, Masahide Goto, Hitoshi Ueda & Susumu Hirose (Feb. 1997). Transcriptional activation through interaction of MBF2 with TFIIA. Genes to Cells, 2 (2): 143-153.

Feng-Qian Li, Archie Coonrod & Marshall Horwitz (Nov. 1996). Preferential MyoD homodimer formation demonstrated by a general method of dominant negative mutation employing fusion with a lysosomal protease. J. Cell Biol., 135 (4): 1043-1057.

Hitoshi Ueda, Ken-Ichi Takemaru, Feng-Qian Li & Susumu Hirose (Jun., 1996). Transcription regulation by FTZ-F1. Protein-Nucleic Acid-Enzyme, 41 (8): 1210-1218. (Review).

Feng-Qian Li, Guan-Cheng Sun, Hitoshi Ueda & Susumu Hirose (Mar., 1995). Sequences of two cDNAs encoding Silkworm homologues of Drosophila melanogaster squid gene. Gene, 154 (2): 295-296.

Feng-Qian Li, Hitoshi Ueda, Susumu Hirose (May. 1994). Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1. Mol. Cell. Biol., 14 (5): 3013-3021.