Graduates of the program (65 to date) are equipped to study major medical problems at the basic science level and to recognize the clinical significance of their pursuits and discoveries. Of our 63 graduates since 1990, many are in faculty positions at prestigious institutions throughout the U.S., including 3 Instructors, 11 Assistant Professors, and 4 Associate Professors. Most of these have been awarded K08, R01, and / or P01 competitive research funding from the NIH or other sources and have demonstrated research productivity since leaving SBU, in many cases with first or senior author publications in top journals such as Science, Nature, Nature Genetics, Nature Medicine, J. Clin. Invest. and Immunity. Most of the 37 graduates who received training grant support (starting with the entering class of 1992) are still in training and only 2 (6%) are in private practice.

MSTP Alumni *reachable via e-mail

Entering Class of 2002:

*De Jesus, Nidia H.
B.A. Skidmore College, 1999
M.D. and Ph.D. in Molecular Genetics and Microbiology, 2009
Dissertation Title: "Impact of Mutating a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site on Biological Properties of Poliovirus and Coxsackievirus A20"
Mentor: Eckard Wimmer, Ph.D., Stony Brook University, Stony Brook, NY
Residency: General Surgery, Lenox Hill Hospital, New York, NY, 2009– present
Selected Publications:
1. Cello, J., Toyoda, H., Dejesus, N., Dobrikova, E. Y., Gromeier, M., and Wimmer, E. 2007. Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses. J Med Virol. 80(2):352-359.
2. De Jesus, N. H. 2007. Epidemics to eradication: the modern history of poliomyelitis. Virol J. 4:70-88.
3. De Jesus, N., Franco, D., Paul, A., Wimmer, E., and J. Cello. 2005. Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence. J Virol. 79(22):14235-14243.

Kontorvoich, Amy R.
B.S. University of Pennsylvania, 2002
M.D. and Ph.D. in Biomedical Engineering, 2009
Dissertation Title: "Finding fluorescent needles in the cardiac haystack: tracking the location and fate of hMSCs with quantum dots for electrical and mechanical repair of damaged myocardium"
Mentor: Ira Cohen, M.D., Ph.D., Stony Brook University, Stony Brook, NY
Residency: Medicine-Research, Mount Sinai Hospital, New York, NY, 2009– present
Selected Publications:
1. Rosen, M.R., Brink, P.R., Cohen, I.S., Danilo Jr., P., Robinson, R.B., Rosen, A.B., and Szabolcs, M.J. Regenerative therapies in electrophysiology and pacing. Journal of Interventional Cardiac Electrophysiology. 22(2):87-98, 2008.
2. Rosen, A.B., Kelly, D.J., Schuldt, A.J.T., Lu, J., Potapova, I.A., Doronin, S.V., Robichaud, K.J., Robinson, R.B., Rosen, M.R., Brink, P.B., Gaudette, G.R., and Cohen, I.S. Finding Fluorescent Needles in the Cardiac Haystack: Tracking human mesenchymal stem cells loaded with quantum dots for quantitative in vivo 3-D fluorescence analysis. Stem Cells. 25(8): 2128 -2138, 2007.
3. Potapova, I.A., Doronin, S.V., Kelly, D.J., Rosen, A.B., Schuldt, A.J.T., Lu, Z., Guo, Y., Kochupura, P.V., Robinson, R.B., Rosen, M.R., Brink, P.R., Gaudette, G.R., and Cohen, I.S. Replacing damaged myocardium. Journal of Electrocardiology. 40(6): S199-S201, 2007.

Entering Class of 2000:

*Ford, Bradley A.
B.S. Cornell University, 1998
M.D. and Ph.D. in Physiology and Biophysics, 2007
Dissertation Title: "Structural & Functional Analysis of Ras Cycling and Inhibition"
Mentor: Nicolas Nassar, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Clinical Pathology, Barnes-Jewish Hospital/Washington University, St. Louis, MO, 2007– present
Description of current clinical and/or research interests: My long-term plan is to secure a co-directorship position in an academic microbiology laboratory and split my time 80/20% between basic research and clinical duties. To that end, I will be entering a postdoctoral position in Molecular Microbiology in January 2008.

Selected Publications:
1. Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N. A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling. Mol Cell. 2007. 27(3):486-97.
2. Ford B, Hornak V, Kleinman H, Nassar N. Structure of a transient intermediate for GTP hydrolysis by ras. Structure. 2006. 14(3):427-36.
3. Ford B, Skowronek K, Boykevisch S, Bar-Sagi D, Nassar N. Structure of the G60A mutant of Ras: implications for the dominant negative effect. J Biol Chem. 2005. 280(27):25697-705.

Kwofie, Michael M.
B.A. Pomona College, 2000
M.D. and Ph.D. in Genetics, 2008
Dissertation Title: "Specific Recognition of RhoGTPases by DOCK 180 family of Guanine Nucleotide Exchange Factors"
Mentor: Jacek Skowronski, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Internal Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, 2008– present
Selected Publications:
1. Kwofie MA, Skowronski J. Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. J Biol Chem. 2008. 283(6):3088-96.
2. Suzuki T, Kwofie MA, Lennarz WJ. Ngly1, a mouse gene encoding a deglycosylating enzyme implicated in proteasomal degradation: expression, genomic organization, and chromosomal mapping. Biochem Biophys Res Commun. 2003. 304(2):326-32.

LaLonde, Mary M.
B.S. Carnegie-Mellon, 1999
M.D. and Ph.D. in Molecular & Cellular Biology, 2007
Dissertation Title: "Investigating the role of Drosophila Phospholipase D in Cellularization and Phototransduction"
Mentor: Michael Frohman, M.D., Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Child Psychiatry, Prelim Stony Brook University Medical Center, Stony Brook, NY, 2008
Fast-Track (Academic Research-oriented) Psychiatry Residency Program at Mt. Sinai (Class of 2012). Her research is connected to child psychiatry."
Selected Publications:
1. LaLonde M, Janssens H, Yun S, Crosby J, Redina O, Olive V, Altshuller YM, Choi SY, Du G, Gergen JP, Frohman MA. A role for Phospholipase D in Drosophila embryonic cellularization. BMC Dev Biol. 2006. 6:60.
2. LaLonde MM, Janssens H, Rosenbaum E, Choi SY, Gergen JP, Colley NJ, Stark WS, Frohman MA. Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid. J Cell Biol. 2005. 169(3):471-9.

McVoy, Lauren A.
B.A. Stony Brook University, 1989
M.D. and Ph.D. in Molecular and Cellular Biology, 2007
Dissertation Title: "Identification of the Vitamin D Binding protein ligands on the Surface of Neutrophils and U937 Cells"
Mentor: Richard Kew, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Clinical Pathology, New York University School of Medicine, New York, NY, 2007– Present
Selected Publications:
1. DiMartino SJ, Trujillo G, McVoy LA, Zhang J, Kew RR. Upregulation of vitamin D binding protein (Gc-globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules. Mol Immunol. 2007. 44(9):2370-7.
2. McVoy LA, Kew RR. CD44 and annexin A2 mediate the C5a chemotactic cofactor function of the vitamin D binding protein. J Immunol. 2005. 175(7):4754-60.
3. Melchor JP, McVoy L, Van Nostrand WE. Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein. J Neurochem. 2000. 74(5):2209-12.

Szema, Robert S.
M.S. Univ. of California-Berkeley, 1999
M.D. and Ph.D. in Biomedical Engineering, 2006
Dissertation Title: "A Scanning Stereoscope for Biomedical Applications"
Mentor: Jahangir Rastegar, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Emergency Medicine, Beth Israel Medical Center, New York, NY, 2006– present
Selected Publications:
Lee LP, Szema R. Inspirations from biological optics for advanced photonic systems.
Science. 2005. 310(5751):1148-50. Review.
2. Tu JK, Huen T, Szema R, Ferrari M. Filtration of sub-100 nm particles using a bulk-micromachined, direct-bonded silicon filter. Biomed Microdevices. 1999. 1(2):113-9.
3. Szema R, Rastegar J, Lee L. An artificial compound eye for stereoendoscopy. J Med Eng Technol. 2004. 28(3):117-24.

Entering Class of 1999:

*Bien, Harold H.
B.S. Johns Hopkins University, 1999
M.D. and Ph.D. in Biomedical Engineering, 2009
Dissertation Title: "Cardiac Arrhythmogenesis In Urban Air Pollution: Optical Mapping In A Tissue-Engineered Model"
Mentor: Emilia Entcheva, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Stony Brook Teaching Hospital, Stony Brook, NY, 2009– present
Selected Publications:
1. Bien H, Parikh P, and Entcheva E. Lenses and effective spatial resolution in macroscopic optical mapping. Physics in Medicine and Biology 52(4):941-960. 2007.
2. Bien H and Entcheva E. Spatial frequency content in optical mapping of cardiac cell monolayers. American Journal of Physiology - Heart and Circ Physiol 291(3):H484-5. 2006.
3. Bien H, Yin L, and Entcheva E. Calcium instabilities in mammalian cardiomyocyte networks. Biophysical Journal 90: 1-13. 2006.

Hsieh, Helen
B.S. Brown University, 1999
M.D. and Ph.D. in Neuroscience, 2008
Dissertation Title: "Mechanisms Underlying AB Mediated Glutamatergic Synaptic Depression"
Mentor: Roberto Malinow, M.D., Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: General Surgery, McGill University Faculty of Medicine/Quebec, Canada, 2008– present
Selected Publications:
1. Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 2006. 52(5):831-43.
2. Boehm J, Ehrlich I, Hsieh H, Malinow R. Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity. Learn Mem. 2006. 13(5):562-5.
3. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 2003. 37(6):925-37.

Ocampo, Christopher J.
B.A. Lafayette College, 1994
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 2007
Dissertation Title: "Determinants & Kinetics of Chronic Immune Activation in HIV-1 Infection"
Mentor: Roy Steigbigel, M.D., and Sidonie Morrison, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Winthrop-University Hospital, Mineola, NY, 2007– present
Selected Publications:
1. Ocampo CJ, Morrison SA, Dubey SA, Shriver JW, Craddock BP, Steigbigel RT. Immune activation in asymptomatic HIV-1-infected individuals during antiretroviral therapy and treatment cessation. Submitted.

Rampal, Raajit K.
B.S. University of Rochester, 1999
M.D. and Ph.D. in Molecular and Cellular Biology, 2007
Dissertation Title: "The Role of O-Fucosylation and Fringe in the Regulation of Notch Signaling"
Mentor: Robert Haltiwanger, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, MD Scientist University of Chicago Medical Center, Chicago, IL, 2007– present
Selected Publications:
1. Rampal R, Luther KB, Haltiwanger RS. Notch signaling in normal and disease States: possible therapies related to glycosylation. Curr Mol Med. 2007. 7(4):427-45.
2. Loriol C, Dupuy F, Rampal R, Dlugosz MA, Haltiwanger RS, Maftah A, Germot A. Molecular evolution of protein O-fucosyltransferase genes and splice variants. Glycobiology. 2006. 16(8):736-47.
3. Rampal R, Li AS, Moloney DJ, Georgiou SA, Luther KB, Nita-Lazar A, Haltiwanger RS. Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats. J Biol Chem. 2005. 23;280(51):42454-63.

Weston, Christi A.
B.A. La Salle University, 1999
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 2006
Dissertation Title: "Signaling Mechanisms that Regulate Acetylcholine Receptor Clustering in Muscle Cells"
Mentor: Joav Prives, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Research Medicine, Dept. of Psychiatry, Columbia Presbyterian, New York, NY, 2006– present
Selected Publications:
1. Weston CA, Teressa G, Weeks BS, Prives J. Agrin and laminin induce acetylcholine receptor clustering by convergent, Rho GTPase-dependent signaling pathways. J Cell Sci. 2007. 120(Pt 5):868-75.
2. Weston C, Gordon C, Teressa G, Hod E, Ren XD, Prives J. Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cells. J Biol Chem. 2003. 278(8):6450-5.
3. Weston CA, Anova L, Rialas C, Prives JM, Weeks BS. Laminin-1 activates Cdc42 in the mechanism of laminin-1-mediated neurite outgrowth. Exp Cell Res. 2000. 260(2):374-8.

Entering Class of 1998:

Archer, Herbert M.
B.S. Cornell University, 1998
M.D. and Ph.D. in Molecular and Cellular Biology, 2005
Dissertation Title: "Inflammation and Cancer: A Unique mouse model of pancreatic disease"
Mentor: Dafna Bar-Sagi, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, NYP Hospital-Columbia Presbyterian, New York, NY, 2005– present
Selected Publications:
1. Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D. A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology. 2006. 131(6):1844-55.
2. Jura N, Archer H, Bar-Sagi D. Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Res. 2005. 15(1):72-7. Review.
3. Archer H, Bar-Sagi D. Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol Biol. 2002. 189:67-73.

*Gambhir, Alok
M.A. Stony Brook University, 1998
M.D. and Ph.D. in Physics and Astronomy, 2006
Dissertation Title: "peptides corresponding to basic/hydrophobic regions of proteins laterally sequester the multivalent acidic lipid PIP2: a mechanism for regulating information flow"
Mentor: Stuart McLaughlin, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Mount Sinai Hospital, New York, NY, 2006–2008
Clinical Fellowship: Cardiology, Columbia NY Presbyterian, New York, NY, 2008– present
Description of current clinical and/or research interests: ABIM research track Cardiology fellowship.
Selected Publications:
1. Rusu L, Gambhir A, McLaughlin S, Rädler J.
Fluorescence correlation spectroscopy studies of Peptide and protein binding to phospholipid vesicles. Biophys J. 2004. 87(2):1044-53.
2. Gambhir A, Hangyás-Mihályné G, Zaitseva I, Cafiso DS, Wang J, Murray D, Pentyala SN, Smith SO, McLaughlin S. Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys J. 2004. 86(4):2188-207.
3. McLaughlin S., Wang J., Gambhir A. & Murray D. (2002) PIP2 and proteins: Interactions, organization, and information flow. Annu. Rev. Biophys. Biomol. Struct. 31: 151-175.

Kassem, Iris S.
B.S. Cornell University, 1998
M.D. and Ph.D. in Neuroscience, 2006
Dissertation Title: "Neural Mechanisms of Hemifacial Spasm"
Mentor: Craig Evinger, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Research Medicine, Dept. of Ophthalmology, North Shore-LIJ, New Hyde Park, NY, 2006– present
Selected Publications:
1. Kassem IS, Evinger C. Asymmetry of blinking. Invest Ophthalmol Vis Sci. 2006. 47(1):195-201.
2. Evinger C, Bao JB, Powers AS, Kassem IS, Schicatano EJ, Henriquez VM, Peshori KR. Dry eye, blinking, and blepharospasm. Mov Disord. 2002. Suppl 2:S75-8.
3. Wade PR, Chen J, Jaffe B, Kassem IS, Blakely RD, Gershon MD. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci. 1996. 16(7):2352-64.

Entering Class of 1997:

*Birnbaum, Anitra S.
B.A. Dartmouth College, 1995
M.D. and Ph.D. in Genetics, 2005
Dissertation Title: "Structural & biochemical studies of the human papillomavirus type 18 replication initiation protein e1"
Mentor: Leemor Joshua-Tor, PhD, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Internal Medicine, Johns Hopkins, MD / Mount Sinai, New York, NY, 2005–2008
Current position: On maternity leave
Selected Publications:
1. Wiberg, K. Birnbaum, AS. Gradon JD. Causes and Presentation of Meningitis in a Baltimore Community Hospital 1997-2006. Southern Medical Journal. (In Press).
2. Birnbaum AS and Gradon JD. 2007. “Deep Neck Infection” Clinical Infectious Disease (third edition of Current Therapy of Infectious Disease). Ed. David Schlossberg. Merion, PA: Cambridge University Press.
3. Auster AS and Joshua-Tor L. 2004. The DNA-binding Domain of Human Papillomavirus Type 18 E1: Crystal Structure, Dimerization, and DNA Binding. Journal of Biological Chemistry. 279(5):3733-3742.

DeLucia-Deranja, Evan O.
B.S. Syracuse University, 1997
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 2005
Dissertation Title: "Cerebral hemodynamic measurements w/intravascular tracers & T2*-weighted echo planar mri: comparison of alternative tracer injection & data analysis paradigms"
Mentor: George C. Newman, M.D., Ph.D., Stony Brook University, Stony Brook, NY
Residency: Psychiatry, SUNY Upstate Medical University, Syracuse, NY, 2004
Current position: Chief, General Adult Psychiatry
Selected Publications:
1. Newman GC, Delucia-Deranja E, Tudorica A, Hospod FE, Patlak CS. Cerebral blood volume measurements by T*2-weighted MRI and contrast infusion. Magn Reson Med. 2003. 50(4):844-55.
2. Tudorica A, Fang Li H, Hospod F, Delucia-Deranja E, Huang W, Patlak CS, Newman GC. Cerebral blood volume measurements by rapid contrast infusion and T2*-weighted echo planar MRI. Magn Reson Med. 2002. 47(6):1145-57.

Grace, Kristen S.
B.S. Stony Brook University, 1997
M.D. and Ph.D. in Molecular and Cellular Biology, 2005
Dissertation Title: "The role of Complement Receptor, gC1qR/p33 in human sperm-egg interaction"
Mentor: Berhane Ghebrehiwet, DVM, D.Sc, Stony Brook University, Stony Brook, NY
Residency: Pediatrics, Einstein/Montefiore Medical Center, Bronx, NY, 2005– Present
Selected Publications:
1. Grace KS, Bronson RA, Ghebrehiwet B. Surface expression of complement receptor gC1q-R/p33 is increased on the plasma membrane of human spermatozoa after capacitation. Biol Reprod. 2002. 66(3):823-9.
2. Friend GJ, Grace KS, Stone HA. Cortical screws versus absorbable pins for fixation of the short Z-bunionectomy. J Foot Ankle Surg. 1994. 33(4):411-8.
3. Grace KS, Allen JO, Newton KJ. R-type plasmids in mitochondria from a single source of Zea luxurians teosinte. Curr Genet. 1994. 25(3):258-64.

Janardhan, Ajit H.
M.S. Boston University, 1997
M.D. and Ph.D. in Genetics, 2005
Dissertation Title: "Identifying host cell factors that mediate HIV-1 nef functions"
Mentor: Jacek Skowronski, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Habor, NY
Residency: PGY-2 Internal Medicine, Barnes-Jewish Hospital, St. Louis, MO, 2005– present
Selected Publications:
1. Janardhan A, Swigut T, Hill B, Myers MP, Skowronski J. HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS Biol. 2004. 2(1):E6.
2. Münch J, Janardhan A, Stolte N, Stahl-Hennig C, Ten Haaft P, Heeney JL, Swigut T, Kirchhoff F, Skowronski J. T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques. J Virol. 2002. 76(23):12360-4.

Kim, Edward J.
B.A. Harvard University, 1997
M.D. and Ph.D. in Genetics, 2005
Dissertation Title: "Characterization of the Calcium Binding -& Dimerization roles for the metastasis-associated Protein S100A4"
Mentor: David Helfman, Ph.D., Cold Spring Harbor Laboratory, Cold Spring, NY
Residency: Internal Medicine, Unv. of Michigan Hospitals, Ann Arbor, MI, 2005– present
Selected Publications:
1. Helfman DM, Kim EJ, Lukanidin E, Grigorian M. The metastasis associated protein S100A4: role in tumour progression and metastasis. Br J Cancer. 2005. 92(11):1955-8. Review.
2. Kim EJ, Helfman DM. Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin. J Biol Chem. 2003. 278(32):30063-73.
3. Araya E, Berthier C, Kim E, Yeung T, Wang X, Helfman DM. Regulation of coiled-coil assembly in tropomyosins. J Struct Biol. 2002. 137(1-2):176-83.

Saxena, Ashish
B.A. New York University, 1997
M.D. and Ph.D. in Genetics, 2006
Dissertation Title: "Mechanisms of Transcription Initiation & RNA Polymerase Specificity: A Study of the Basal transcription Factors TFIIB & Brf2"
Mentor: Nouria Hernandez, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Internal Medicine Einstein/Montefiore Med Center, Bronk, NY, 2006– present
Selected Publications:
1. Saxena A, Ma B, Schramm L, Hernandez N. Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription. Mol Cell Biol. 2005. (21):9406-18.

Entering Class of 1996:

Hill, Brian T.
B.A. Dartmouth College, 1996
Ph.D. in Genetics, 2003 (transferred to Unv. of Illinois at Chicago College of Medicine)
Dissertation Title: "Characterization of a Novel Complex Containing HIV-1 Nef & N-Myristoyltransferase"
Mentor: Jacek Skowronski, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Univ. of Illinois at Chicago College of Medicine, Chicago, IL
Selected Publications:
1. Hill BT, Kondapalli L, Artz A, Smith S, Rich E, Godl ey L, Odenike O, Pursell KJ, Larson RA, Stock W, van Besien K. Successful allogeneic transplantation of patients with suspected prior invasive mold infection. Leuk Lymphoma. 2007. 48(9):1799-805.
2. Fliszar KA, Hill BT, Foster N. Predicting human drug pharmacokinetics from in vitro permeability using an absorption-disposition model. J Pharm Sci. 2007. 96(8):2161-70.
3. Hill BT, Skowronski J. Human N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins. J Virol. 2005. 79(2):1133-41.

*Kamenetz, Flavio R.
B.A. Columbia University, 1996
M.D. and Ph.D. in Genetics, 2004
Dissertation Title: "APP Processing and Synaptic Function"
Mentor: Roberto Malinow, M.D., Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Internal Medicine, Lenox Hill Hospital, New York, NY, 2004-2005
Current position: Diagnostic Radiology/PGY-5, Beth Israel Medical Center, New York, NY, 2005– present
Description of current clinical and/or research interests: (several sentence description)
Selected Publications:
1. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 2003. 37(6):925-37.

*Manganas, Louis N.
B.S. Stony Brook University, 1994
M.D. and Ph.D. in Biochemistry & Cellular Biology, 2004
Dissertation Title: "Trafficking of Voltage-Gated kv1 Channels"
Mentor: James Trimmer, Ph.D., Stony Brook University, Stony Brook, NY
Post-doc Fellowship: 1-year postdoctoral fellowship, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 2004-2005
Residency: Neurobiology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 2004-2005
Current position: Resident, Pediatrics, Stony Brook University, Stony Brook, NY, 2006– present
Selected Publications:
1. Maletic-Savatic M, Vingara LK, Manganas LN, Li Y, Zhang S, Sierra A, Hazel R, Smith D, Wagshul ME, Henn F, Krupp L, Enikolopov G, Benveniste H, Djuric PM, Pelczer I. Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery. Cold Spring Harb Symp Quant Biol. 2008. Ahead of Print.
2. Manganas LN, Zhang X, Li Y, Hazel RD, Smith SD, Wagshul ME, Henn F, Benveniste H, Djuric PM, Enikolopov G, Maletic-Savatic M. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science. 2007. 318(5852):980-5.
3. Manganas LN, Maletic-Savatic M. Stem cell therapy for central nervous system demyelinating disease. Curr Neurol Neurosci Rep. 2005. 5(3):225-31. Review.

Mittra, Erik S.
B.A. University of California-Berkeley, 1996
M.D. and Ph.D. in Biomedical Engineering, 2005
Dissertation Title: "Non-invasive assessment of trabecular bone quantity & quality using microstructure, micro-mechanics & micro-finite element modeling"
Mentor: Yi-Xian Qin, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Nuclear Medicine Residency Program, Stanford University, Stanford, CA, 2006– present
Selected Publications:
1. Iagaru AH, Mittra ES, McDougall IR, Quon A, Gambhir SS. 18F-FDG PET/CT evaluation of patients with ovarian carcinoma. Nucl Med Commun. 2008. 29(12):1046-51.
2. Mittra ES, Niederkohr RD, Rodriguez C, El-Maghraby T, McDougall IR. Uncommon causes of thyrotoxicosis. J Nucl Med. 2008. 49(2):265-78. Review.
3. Mittra ES, McDougall IR. Recurrent silent thyroiditis: a report of four patients and review of the literature. Thyroid. 2007. 17(7):671-5.

Entering Class of 1995:

Bell, James III
B.A. SUNY at Binghamton, 1989
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 2004
Dissertation Title: "A Genetic study of Fear-Potentiation of Startle in Mice Using the Quantitative Trait Loci Approach"
Mentor: Robert Hitzemann, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Dept. of Anesthesiology/PGY-2, Stony Brook University Hospital, NY, 2005– present
Selected Publications:
1. McCaughran JA Jr, Bell J 3rd, Hitzemann RJ. Fear-potentiated startle response in mice: genetic analysis of the C57BL/6J and DBA/2J intercross. Pharmacol Biochem Behav. 2000. 65(2):301-12.
2. Ueda S, Kokotos Leonardi ET, Bell J 3rd, Azmitia EC. Serotonergic sprouting into transplanted C-6 gliomas is blocked by S-100 beta antisense gene. Brain Res Mol Brain Res. 1995. 29(2):365-8.
3. Bell J 3rd, Zhang XN, Whitaker-Azmitia PM. 5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents. Brain Res. 1992. 571(2):293-7.

Bhatt, Dimple H.
M.S. New York University, 1994
M.D. and Ph.D. in Neuroscience, 2006
Dissertation Title: "Identification, disruption and repair of spinal circuitry int he zebrafish"
Mentor: Joseph R. Fetcho, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Psychiatry, NYP Hospital-Weill Cornell Medical Center, New York, NY, 2006– present
Selected Publications:
1. Bhatt DH, McLean DL, Hale ME, Fetcho JR. Grading movement strength by changes in firing intensity versus recruitment of spinal interneurons. Neuron. 2007. 53(1):91-102.
2. Fetcho JR, Bhatt DH. Genes and photons: new avenues into the neuronal basis of behavior. Curr Opin Neurobiol. 2004. 14(6):707-14. Review.
3. Bhatt DH, Otto SJ, Depoister B, Fetcho JR. Cyclic AMP-induced repair of zebrafish spinal circuits. Science. 2004. 305(5681):254-8.

Chabra, Inderjit S.
B.S. Stanford University, 1995
M.D. and Ph.D. in Molecular Genetics and Microbiology, 2008
Dissertation Title: "Adenovirus-AAV Hybrid Vectors for Gene Therapy"
Mentor: Patrick Hearing, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Medicine, UPMC Med. Education Prog-PA / Transitional / Dermatiology, 2008– present
Selected Publications:
1. Hornbeck PV, Chabra I, Kornhauser JM, Skrzypek E, Zhang B. PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Proteomics. 2004. 4(6):1551-61.
2. Chabra I and Hearing P. Utilization of a new adenovirus E1-, adeno-associated virus Rep-expressing cell line to readily produce gutted Ad vectors. Submitted.
3. Chabra I and Hearing P. Specific Integration into the Human AAVS1 Locus sing an Ad/AAV Hybrid Virus. In preparation.

Chimes, Gary P.
B.A. Dartmount College, 1994
M.D. and Ph.D. in Anatomical Sciences, 2002
Dissertation Title: "Factors Associated with Variation in Overhead Throwing Performance by Females"
Mentor: Jack T. Stern, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Department of Physical Medicine & Rehabilitation, UMDNJ-NJMS, Newark, NJ, 2002–2004

*Indyk, Justin A.
B.S. University of California San Diego, 1995
M.D. and Ph.D. in Genetics, 2004
Dissertation Title: "Exploring the Role of Laminin in Neurodegeneration in the Mammalian Central Nercous System"
Mentor: Sidney Strickland, Ph.D., and Styliani-Anna Tsirka, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Pediatrics, Children's Hospital of Pittsburgh, Pittsburg, PA, 2004–2007
Current position: Fellow, Pediatric Endocrinology: 2007– present
Description of current clinical and/or research interests: Glucocorticoid receptor signalling in critical illness and disease states
Selected Publications:
1. Chen Z-l, Indyk JA, Bugge TH, Kombrinck KW, Degen JL, Strickland S. Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes. 1999. J Neuroscience. 19(22):9813-9820.
2. Chen Z-l, Indyk JA, Strickland S. The hippocampal laminin matrix is dynamic and critical for neuronal survival. 2003. Molecular Biology of the Cell. 14:2665-2676.
3. Indyk JA, Chen Z-l, Tsirka SE, Strickland S. Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injury. 2003. Neuroscience. 116(2):359-71.

Entering Class of 1994:

Dougherty, Douglas A.
B.A. The University of Virginia, 1989
M.D. and Ph.D. in Anatomical Sciences, 2001
Dissertation Title: "Autoradiographic-based biological phantom for emission tomography"
Mentor: Gene Gindi, Ph.D., Stony Brook University, Stony Brook, NY
Internship: Internal Medicine, Dept. of Radiology, Stony Brook University, Stony Brook, NY, 2001-2002
Research Fellowship: Dept. of Neuroradiology, University of Miami, Jackson Memorial Hospital, Miami, FL
Current position: Neuroradiology, Unv. of Miami, Jackson Memorial Hospital, Miami, FL
Selected Publications:
1. Gleitsman KR, Kedrowski SM, Lester HA, Dougherty DA. An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating. J Biol Chem. 2008. 283(51):35638-43.
2. Dougherty DA. Cys-loop neuroreceptors: structure to the rescue? Chem Rev. 2008. 108(5):1642-53.
3. Dougherty DA. Physical organic chemistry on the brain. J Org Chem. 2008. 73(10):3667-73.

*Levine, Robert L.
B.S. Stony Brook University, 1994
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 2003
Dissertation Title: "Mutagenesis induced by ethenodeoxyadenosin in himan cells"
Mentor: Masaaki Moriya, D.V.M., Ph.D., Stony Brook University, Stony Brook, NY
Residency: Pediatrics, Stony Brook University Hospital, Stony Brook, NY, 2003
Selected Publications:
1. Levine RL, Miller H, Grollman A, Ohashi E, Ohmori H, Masutani C, Hanaoka F, Moriya M. Translesion DNA synthesis catalyzed by human pol eta and pol kappa across 1,N6-ethenodeoxyadenosine. J Biol Chem. 2001. 276(22):18717-21.
2. Levine RL, Yang IY, Hossain M, Pandya GA, Grollman AP, Moriya M. Mutagenesis induced by a single 1,N6-ethenodeoxyadenosine adduct in human cells. Cancer Res. 2000. 60(15):4098-104.

*Seandel, Marco
B.A. Dartmount College, 1994
M.D. and Ph.D. in Cellular & Molecular Pathology, 2002
Dissertation Title: "Vivo: Requirement for Matrix Metalloproteinases Activity and Type I Collagen Cleavage"
Mentor: Mary Kritzer, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Pediatric Neurology, New York Presbyterian Hospital, New York, NY, 2002–2004
Clinical Fellowship: Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 2004
Research Fellowship: Postdoctoral fellowship, Ansary Stem Cell Center for Regenerative Medicine, laboratory of Dr. Shahin Rafi (Howard Hughes Medical Institute), Weill Medical College, New York, NY, 2004
Current position: Medical Oncology Fellow, New York Presbyterian Hospital, New York, NY, 2006– present
Selected Publications:
1. Seandel M, Butler JM, Kobayashi H, Hooper AT, White IA, Zhang F, Vertes EL, Kobayashi M, Zhang Y, Shmelkov SV, Hackett NR, Rabbany S, Boyer JL, Rafii S. Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene. Proc Natl Acad Sci U S A. 2008. 105(49):19288-93.
2. Kim J, Seandel M, Falciatori I, Wen D, Rafii S. CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells. Stem Cells. 2008. 26(10):2516-22.
3. Seandel M, Butler J, Lyden D, Rafii S. A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization. Cancer Cell. 2008. 13(3):181-3.

Venkatesan, Charulata
B.A. Columbia University, 1992
M.D. and Ph.D. in Neuroscience, 2002
Dissertation Title: "The influence of postnatal gonadal hormone exposure on circuit organization in the cerebral cortex"
Mentor: Mary Kritzer, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Pediatric Neurology, Northwestern University, Chicago, IL
Selected Publications:
1. Balasubramanian G, Sarathi M, Venkatesan C, Thomas J, Hameed AS. Studies on the immunomodulatory effect of extract of Cyanodon dactylon in shrimp, Penaeus monodon, and its efficacy to protect the shrimp from white spot syndrome virus (WSSV). Fish Shellfish Immunol. 2008. 25(6):820-8.
2. Venkatesan C, Wainwright MS. Pediatric endocarditis and stroke: a single-center retrospective review of seven cases. Pediatr Neurol. 2008. 38(4):243-7.
3. Venkatesan C, Kritzer MF. Perinatal gonadectomy affects corticocortical connections in motor but not visual cortex in adult male rats. J Comp Neurol. 1999. 415(2):240-65.

Entering Class of 1993:

*Asch, William S.
B.A. Brandeis University, 1993
M.D. and Ph.D. in Molecular and Cellular Biology, 2001
Dissertation Title: "Studies on the zebrafish neuronal intermediate filament protein plasticin: implications for axonal flexibility"
Mentor: Nisson Schechter, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Yale University, New Haven, CT, 2001-2003
Clinical Fellowship: Nephrology, 2004-2008
Research Fellowship: Nephrology, laboratory of Dr. Richard Lifton, 2005–2008
Current position: Clinical Assistant Professor, Yale New Haven Organ Transplantation Center, Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 2008- present
Description of current clinical and/or research interests:
- care of the post-kidney transplant patient.
- evaluation of kidney transplant recipient candidates
- living kidney donor evaluations
- unique aspects of hypertension in the kidney transplant recipient.
- BK nephropathy
Selected Publications:
1. Asch WS, Schechter N. Plasticin, a type III neuronal intermediate filament protein, assembles as an obligate heteropolymer: implications for axonal flexibility. J Neurochem. 2000. 75(4):1475-86.
2. Leake D, Asch WS, Canger AK, Schechter N.Gefiltin in zebrafish embryos: sequential gene expression of two neurofilament proteins in retinal ganglion cells. Differentiation. 1999. 65(4):181-9.
3. Passini MA, Kurtzman AL, Canger AK, Asch WS, Wray GA, Raymond PA, Schechter N.Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. Dev Genet. 1998. 23(2):128-41.

Chen, Grace Y. (Henry)
B.A. Harvard College, 1993
Ph.D. in Genetics, 1999 (transferred to Unversity of Michigan Medical School)
Mentor: Arne Stenlund, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Department of Medicine, University of Michigan Medical School, Ann Arbor, MI
Selected Publications:
1. Chen G, Stenlund A. Sequential and ordered assembly of E1 initiator complexes on the papillomavirus origin of DNA replication generates progressive structural changes related to melting. Mol Cell Biol. 2002. 22(21):7712-20.
2. Chen G, Stenlund A.The E1 initiator recognizes multiple overlapping sites in the papillomavirus origin of DNA replication. J Virol. 2001. 75(1):292-302.
3. Enemark EJ, Chen G, Vaughn DE, Stenlund A, Joshua-Tor L. Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus. Mol Cell. 2000. 6(1):149-58.

Entering Class of 1992:

*Dranovsky, Alexander
B.A., Boston University, 1992
M.D. and Ph.D. in Cellular and Molecular Pathology, 2000
Dissertation Title: "Nucleolin in Mitosis and in Alzheimer's Disease Pathology"
Mentor: Dmitry Goldgaber, Ph.D., Stony Brook University, Stony Brook, NY
Internship: NY-Presbyterian/Columbia Unv. Medical Center, New York, NY, 2000-2001
Residency: Dept. of Psychiatry, Columbia University Medical Center, New York State Psychiatric Institute, 2001-2004
Fellowship: Columbia University Medical Center, New York State Psychiatric Institute, New York, NY, 2004-2006
Current position: Assistant Professor of Clinical Psychiatry
Selected Publications:
1. Wang JW, Dranovsky A, Hen R. The when and where of BDNF and the antidepressant response. Biol Psychiatry. 2008. 1;63(7):640-1. Review.
2. Dranovsky A, Hen R. DISC1 puts the brakes on neurogenesis. Cell. 2007. 130(6):981-3.
3. Dranovsky A, Hen R. Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry. 2006. 59(12):1136-43. Review.

Rogove, Andrew D.
B.S. Massachusetts Institute of Technology, 1992
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 2000
Dissertation Title: "Exploring the Role of the Plasminogen Activator System in Microglial Activation & Neuronal Degeneration"
Mentor: Styliani-Anna Tsirka, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Dept. of Neurology, NY Presbyterian/Cornell Hospital, New York, NY
Current position: Private Practice
Selected Publications:
1. Gao Z, Wang J, Thiex R, Rogove AD, Heppner FL, Tsirka SE. Microglial activation and intracerebral hemorrhage. Acta Neurochir Suppl. 2008. 105:51-3.
2. Sheehan JJ, Zhou C, Gravanis I, Rogove AD, Wu YP, Bogenhagen DF, Tsirka SE. Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice. J Neurosci. 2007. 27(7):1738-45.
3. Rogove AD, Lu W, Tsirka SE. Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration. Cell Death Differ. 2002 Aug;9(8):801-6.

Entering Class of 1991:

DiMartino, Stephen J.
B.S. Carnegie-Mellon University, 1991
M.D. and Ph.D. in Cellular and Molecular Pathology, 1999
Dissertation Title: "Investigation of the C5a Co-chemotactic Mechanism of the Vitamin D Binding Protein"
Mentor: Richard Kew, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, New York-Presbyterian Hospital-Cornell, New York, NY
Research Fellowship: Dept. of Reheumatology, Hospital for Special Surgery, laboratory of Dr. Jane Salmon
Current position: Assistant Attending Physician, Reheumatology Department, Hospital for Special Surgery
Description of current clinical and/or research interests: Co-investigator on the RAVE trial (Rituximab in ANCA associated vasculitis) and hope to use this experience to eventually develop my own translational research interests.
Selected Publications:
1. DiMartino SJ. Idiopathic inflammatory myopathy: treatment options. Curr Rheumatol Rep. 2008. 10(4):321-7.
2. DiMartino SJ, Yuan W, Redecha P, Ivashkiv LB, Salmon JE. Insoluble immune complexes are most effective at triggering IL-10 production in human monocytes and synergize with TLR ligands and C5a. Clin Immunol. 2008. 127(1):56-65.
3. DiMartino SJ, Trujillo G, McVoy LA, Zhang J, Kew RR. Upregulation of vitamin D binding protein (Gc-globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules. Mol Immunol. 2007. 44(9):2370-7.

Iafrate, John A.
B.A. Yale University, 1991
M.D. and Ph.D. in Molecular Genetics and Microbiology, 2000
Dissertation Title: "Multiple Functions of HIV & SIV Nef: Mechanisms & Importance"
Mentor: Jacek Skowronski, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Dept. of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 2000-2004
Research Fellowship: Postdoctorial Fellow, Brigham and Women's Hospital, laboratory of Dr. Charles Lee.
Current position: Director of Diagnostic Molecular Pathology, Pathology Department, Assistant Pathologist, Massachusetts General Hospital, Boston, MA
Selected Publications:
1. Carl S, Iafrate AJ, Lang SM, Stolte N, Stahl-Hennig C, Mätz-Rensing K, Fuchs D, Skowronski J, Kirchhoff F. Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques. J Virol. 2000. 74(9):4155-64.
2. Iafrate AJ, Carl S, Bronson S, Stahl-Hennig C, Swigut T, Skowronski J, Kirchhoff F. Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J Virol. 2000. 74(21):9836-44. Erratum in: J Virol. 2000. 74(24):12002.
3. Skowronski J, Greenberg ME, Lock M, Mariani R, Salghetti S, Swigut T, Iafrate AJ. HIV and SIV Nef modulate signal transduction and protein sorting in T cells. Cold Spring Harb Symp Quant Biol. 1999. 64:453-63. Review.

Lee, Benjamin H.
A.B. Princeton University, 1991
M.D. and Ph.D. in Molecular Genetics and Microbiology, 1999
Dissertation Title: "Regulation of the human proliferating cell nuclear antigen promoter by the adenovirus E1A 243R oncogene"
Mentor: Michael B. Matthews, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Anatomic Pathology, Brigham & Women's Hospital, Boston, MA, 1999-2001
Clinical Fellowship: Hematopathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 2001-2002
Research Fellowship: Dept. of Pathology, Postdoctoral research tenure, Brigham & Women's Hospital, Harvard Medical School
Selected Publications:
1. Kindler T, Cornejo MG, Scholl C, Liu J, Leeman DS, Haydu JE, Fröhling S, Lee BH, Gilliland DG. K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. Blood. 2008. 112(8):3373-82.

Entering Class of 1990:

Alexander, Daniela S.
B.E. Stony Brook University, 1990
M.D. and Ph.D. in Cellular and Molecular Pathology, 1998
Mentor: James Quigley, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Medical University of Rochester Strong Memorial, Rochester, NY
Selected Publications:
1. Alexander DS, Sipley JD, Quigley JP. Autoactivation of avian urokinase-type plasminogen activator (uPA). A novel mode of initiation of the uPA/plasmin cascade. J Biol Chem. 1998. 273(13):7457-61.
2. Sipley JD, Alexander DS, Testa JE, Quigley JP. Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1. Proc Natl Acad Sci U S A. 1997. 94(7):2933-8.
3. Alexander DS, Aimes RT, Quigley JP. What structure and function of avian plasminogen activator and matrix metalloproteinase-2 reveal about their counterpart mammalian enzymes, their regulation and their role in tumor invasion. Enzyme Protein. 1996. 49(1-3):38-58. Review.

Lieberfarb, Marshal E.
B.S. Mass Institute of Technology, 1990
M.D. and Ph.D. in Cellular and Molecular Pathology, 1998
Mentor: Sidney Strickland, Ph.D., Stony Brook University, Stony Brook, NY
Current position: Private Practice
Selected Publications:
1. Lieberfarb ME, Lin M, Lechpammer M, Li C, Tanenbaum DM, Febbo PG, Wright RL, Shim J, Kantoff PW, Loda M, Meyerson M, Sellers WR. Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP. Cancer Res. 2003. 63(16):4781-5.
2. Lieberfarb ME, Schultz D, Whittington R, Malkowicz B, Tomaszewski JE, Weinstein M, Wein A, Richie JP, D'Amico AV. Using PSA, biopsy Gleason score, clinical stage, and the percentage of positive biopsies to identify optimal candidates for prostate-only radiation therapy. Int J Radiat Oncol Biol Phys. 2002. 53(4):898-903.
3. Wreden C, Verrotti AC, Schisa JA, Lieberfarb ME, Strickland S. Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA. Development. 1997. 124(15):3015-23.

Sims, Matthew D.
B.S. Stony Brook University, 1990
M.D. and Ph.D. in Genetics, 2000
Dissertation Title: "Molecular Characterization of Pimaricin Resistance in Dictypstelium Discoideum"
Mentor: Eugene R. Katz, Ph.D., Stony Brook University, NY
Residency: Internal Medicine, Stony Brook University, Stony Brook, NY
Research Fellowship: Infectious Disease, University of Rochester Medical Center, Rochester, NY
Description of current clinical and/or research interests: My current research goals utilize basic research methodologies and tools to obtain results that have clinical implication and application. It blends my interest in bench research and talents in abstract problem solving with my desire to care for patients.
Selected Publications:
1. Jiang YW, Sims MD, Conway DP. The efficacy of TAMUS 2032 in preventing a natural outbreak of colibacillosis in broiler chickens in floor pens. Poult Sci. 2005. 84(12):1857-9.
2. Duffy CF, Sims MD, Power RF. Evaluation of dietary Natustat for control of Histomonas meleagridis in male turkeys on infected litter. Avian Dis. 2005. 49(3):423-5.
3. Sims MD, Dawson KA, Newman KE, Spring P, Hoogell DM. Effects of dietary mannan oligosaccharide, bacitracin methylene disalicylate, or both on the live performance and intestinal microbiology of turkeys. Poult Sci. 2004. 83(7):1148-54.

Entering Class of 1989:

*Kim, Jiyun V.
B.S. Stony Brook University, 1985
M.D. and Ph.D. in Physiology and Biophysics, 1996
Dissertation Title: "The role of electrostatics in reversible binding of MARCKS to membranes"
Mentor: Stuart K. McLaughlin, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Intern and resident, Internal Med., The New York Presbyterian Hospital, Weill-Cornell Medical College, NY, 1996-1998
Clinical Fellowship: Hematology & Oncology, The New York Presbyterian Hospital, Weill-Cornell Medical College, NY, 1998-2002
Research fellowship: National Cancer Institute, Surgery branch, Bethesda, MD, 2002
Clinical Scholar, Sloan-Kettering, NY, 2003
Postdoctoral Fellow: Skirball Institute, Molecular Pathogenesis Program, New York University School of Medicine, New York, NY Lab of Michael Dustin, Ph.D., 2004-2008
Current position: Research Assistant Professor of Pathology, Dustin Laboratory, NYU School of Medicine, New York, NY
Description of current clinical and/or research interests: The focus of my research is to understand the maintenance and breakdown in blood brain barrier in various disease models including autoimmunity and infection. This is achieved by visualizing immune cell dynamics in vivo using two photon microscopy. The central nervous system innate immune response by the glia is studied as well as the peripheral immune cell invasion.
Selected Publications:
1. Kim JV, Jiang N, Tadokoro CE, Liu L, Ransohoff RM, Lafaille JJ, Dustin ML. Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods. 2009 Oct 2. [Epub ahead of print]
2. Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2009 Jan 8;457(7226):191-5.
3. Kim, J.V.*, Kang, S.S.*, Dustin, M.L, McGavern, D.B. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2008. doi: 10.1038.

Entering Class of 1988:

*Kutok, Jeffery L.
B.S. Stony Brook University, 1988
M.D. and Ph.D. in Cellular and Molecular Pathology, 1995
Dissertation Title: "Partial inhibition of platelet function by a murine monoclonal antibody
that binds to all glycoprotein IIIa molecules: Requirement for antibody bivalency"
Mentor: Barry Coller, M.D., Stony Brook University, Stony Brook, NY
Residency: Anatomic Pathology, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, 1995-1997
Clinical Fellowship: Hematopathology, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, 1997-1998
Research Fellowship: Dept. of Pathology and Medicine, Brigham & Women’s Hospital, Harvard Medical School, laboratory of Dr. Gary Gilliland, 1998-2000
Current position: Associate Professor of Pathology, Harvard Medical School: 2005– present
Description of current clinical and/or research interests:
Currently, I am engaged in research focused on the identification of biomarkers will identify therapeutic targets of diffuse large cell lymphoma, Hodgkin Lymphoma, and Acute Leukemias.
Selected Publications:
1. Rodig SJ, Ouyang J, Juszczynski P, Currie T, Law K, Neuberg DS, Rabinovich GA, Shipp MA, Kutok JL. AP1-dependent Galectin-1 Expression Delineates Classical Hodgkin and Anaplastic Large Cell Lymphomas from Other Lymphoid Malignancies with Shared Molecular Features. Clin Cancer Res. 2008. 14(11):3338-44.
2. Rodig SJ, Savage KJ, LaCasce AS, Weng AP, Harris NL, Shipp MA, Hsi ED, Gascoyne RD, Kutok JL. Expression of TRAF1 and Nuclear c-Rel Distinguishes Primary Mediastinal Large Cell Lymphoma from Other Types of Diffuse Large B Cell Lymphoma. Am J Surg Path. 2007. 31(1):106-12.
3. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science. 2007. 27;316(5824):604-8.

Pessler, Frank
B.S. Utah State University, 1985
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 1998
Dissertation Title: "Protein complexes on the HIV-1 promoter"
Mentor: Nouria Hernandez, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Residency: Pediatrics, New York University Medical Center and Bellevue Hospital Center, New York, NY
Current position: Fellow, Division of Rheumatology, The Children's Hospital of Philadelphia, PA, 2003–
Visiting Scientist, Merck Research Laboratories, Rahway, 2003–
Attending Physician (per diem), Holy Redeemer Hospital Inpatient Pediatrics, 2004–
Selected Publications:
1. Pessler F, Hernandez N. Flexible DNA binding of the BTB/POZ-domain protein FBI-1. J Biol Chem. 2003. 278(31):29327-35.
2. Pessler F, Hernandez N.Th e HIV-1 inducer of short transcripts activates the synthesis of 5,6-dichloro-1-beta-D-benzimidazole-resistant short transcripts in vitro. J Biol Chem. 1998. 273(9):5375-84.
3. Pessler F, Pendergrast PS, Hernandez N. Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts. Mol Cell Biol. 1997. 17(7):3786-98.

Entering Class of 1987:

Kanes, Stephen J.
B.A. University of Pennsylvania, 1986
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 1995
Dissertation Title: "Genetic Analysis of Neuroleptic Sensitivity."
Mentor: Robert J. Hitzemann, Ph.D., Stony Brook University, NY
Residency: Psychiatry, Yale University, New Haven, CT, 1995-1998
Current position: Assistant Professor, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
Description of current clinical and/or research interests: Visual Attention Circuitry in Schizophrenia Investigated With Oddball Event-Related Functional Magnetic Resonance Imaging

*Sharma, Nutan
A.B. Stanford University, 1986
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 1995
Dissertation Title: "Sharma N. Characterization of Kv2.1 in PC12 cells"
Mentor: James Trimmer, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Evanston Hospital, Evanston, IL, 1995-1996
Clinical Fellowship: Department of Neurology, Yale University, New Haven, CT, 1996-1999
Research Fellowship: Neurology, Movement Disorders, Massachusetts General Hospital, Baltimore, MD, 1999-2001
Current position: Assistant Professor, Department of Neurology, Harvard Medical School - Massachussetts General Hospital, 2001–
Description of current clinical and/or research interests: Current research focuses on the generation and characterization of rodent models of DYT1 dystonia. Specifically, I have focused on the phenotypic, anatomic andbiochemical characterization of a transgenic mouse expressing the human DYT1gene. I am currently developing alternative mouse models, including a knock-in and conditional knock-out mouse, to develop a better mammalian model of DYT1dystonia. A parallel focus of work is in the systemic, long-term characterization of the clinical features of dystonia in humans. In addition, DNA is collected from patients involved in the study and analyzed for the presence of the DYT1 mutation. The DNA is also stored and studied for the identification of other genes that play a role in the development of a dystonic phenotype.
Selected Publications:
1. Jinnah, H, Hess, E, LeDoux, M, Sharma, N, Baxter, M, DeLong, M Rodent Models for Dystonia Research: Characteristics, Evaluation and Utility. Mov Disord. 2005. 20(3):283-292.
2. Sharma, N., and Richman, E. Parkinson’s Disease and the Family, Harvard University Press, Cambridge MA. 2005.
3. Sharma N, Baxter M, Petravicz J, Bragg CD, Schienda A, Standaert DG, Breakefield XO Impaired Motor Learning in Mice Expressing TorsinA with the DYT1 Dystonia Mutation. J Neurosci. 2005. 25:5351-5355.

*Tchou, Julia C.
B.S. College of Mount St. Vincent, 1987
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 1995
Dissertation Title: "Repair of DNA by 8-oxoguanine DNA-glycosylase, FPG protein"
Mentor: Arthur P. Grollman, M.D., Stony Brook University, Stony Brook, NY
Residency: General Surgery, Johns Hopkins Hospital, Baltimore, MD, 1995-2001
Clinical Fellowship: GI surgery Fellowship at Johns Hopkins Hospital, Baltimore, MD, 2002-2003
Research Fellowship: Breast Surgery Fellowship at Northwestern Memorial Hospital, Chicago, IL, 2002 -2003.
Current position: Assistant Professor, Department of Surgery, University of Pennsylvania, PA, 2003– present
Description of current clinical and/or research interests: Dr. Tchou’s career interest is focused on defining the biology that drives breast cancer progression in two model systems: 1) the progression from normal breast epithelium to invasive breast cancer and 2) the progression from primary breast tumors to the development of local or distant failure. Her recent proposed research is focused on the role of P-cadherin, a cell-cell adhesion molecule, in breast carcinogenesis.
Selected Publications:
1. Tchou J, Hou N, Rademaker A, Jordan VC, Morrow M. Acceptance of tamoxifen chemo-prevention by physicians and women at risk. Cancer. 2004. 100(9):1800-1806.
2. Tchou J, Morrow M. Available models for breast cancer risk assessment: How accu-rate are they? Journal of American College of Surgeons. 2003. 197(6):1029-1035.
3. Tchou JC, Lin X, Freije D, Isaacs WB, Brooks JD, Rashid A, De Marzo AM, Kanai Y, Hirohashi S, Nelson WG. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. International Journal of Oncology. 2000. 16(4):663-76.

Entering Class of 1986:

*Bunz, Fred
B.S. Stony Brook University, 1986
M.D. and Ph.D. in Cellular and Molecular Biology, 1995
Dissertation Title: "Studies of DNA Replication Factor C"
Mentor: Bruce W. Stillman, Ph.D., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Postdoctoral Fellowship: Johns Hopkins Medical Research Center, Baltimore, MD, 1994-2000
Research Fellowship: Research Associate, Johns Hopkins Oncology Center and Howard Hughes Medical Institute, Johns Hopkins University, laboratory of Drs. Bert Vogelstein and Ken Kinzler, 1994-2000.
Current position: Associate Professor of Radiation Oncology and Molecular Radiation Sciences, with a joint appointment in Cellular and Molecular Medicine. Member, The Sidney Kimmel Comprehensive Cancer Center. Director, Cell Imaging Core Facility, The Johns Hopkins University School of Medicine, Baltimore, MD, 2005–
Director, Radiation Oncology Training Fellowship: 2008–
Description of current clinical and/or research interests: Studies in the Bunz laboratory are focused on how DNA damage signaling affects the regulation of the cell cycle and cell survival. A growing body of evidence suggests that the genes involved in the DNA damage responses also play an important role in sensing the early oncogenic changes that occur as cancers develop from normal precursor cells. The laboratory is dedicated to studying the effects of radiation and therapeutic drugs on cancer cells and normal tissues.
Selected Publications:
1. Hurley PJ, Bunz F. 2007. ATM and ATR: components of an integrated circuit. Cell Cycle. 6:414-7.
2. Wilsker D, Bunz F. 2007. Loss of Ataxia telangiectasia mutate- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival. Mol Cancer Ther. 6:1406-13.
3. Rago C, Vogelstein B, Bunz F. 2007. Genetic knockouts and knockins in human somatic cells. Nat Protoc. 2:2734-46.
Published book: Principles of Cancer Genetics

Druger, Robert K.
B.S. Syracuse University, 1986
M.D. and Ph.D. in Biochemistry & Molecular Biology, 1994
Mentor: Nisson Schechter, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Medicine, Washington School of Medicine, St. Louis, MO, 1998
Current position: Clinical Instructor of Ophthalmology; Private Practice
Selected Publications:
1. Glasgow E, Druger RK, Fuchs C, Levine EM, Giordano S, Schechter N. Cloning of multiple forms of goldfish vimentin: differential expression in CNS. J Neurochem. 1994. 63(2):470-81.
2. Fuchs C, Druger RK, Glasgow E, Schechter N. Differential expression of keratins in goldfish optic nerve during regeneration. J Comp Neurol. 1994. 343(2):332-40.
3. Druger RK, Glasgow E, Fuchs C, Levine EM, Matthews JP, Park CY, Schechter N. Complex expression of keratins in goldfish optic nerve. J Comp Neurol. 1994. 340(2):269-80.

*Sanacora, Gerard
B.S. Stony Brook University, 1986
M.D. and Ph.D. in Physiology & Biophysics, 1994
Dissertation Title: "Insulin Regulation of Neuropeptide Y Gene Expression"
Mentor: Jeffrey D. White, Ph.D. and Michael Berelowitz, M.D., Stony Brook University, Stony Brook, NY
Residency: Psychiatry, Yale-New Haven Hospital, New Haven, CT, 1994-1995
Clinical Fellowship: Clinical Neuroscience Research Training Program, Yale University, New Haven, CT, 1994-1998
Research Fellowship: Dept. of Neuroimaging, Neuroimaging Scientist Training Program, Yale University, New Haven, CT
Current position: Associate Professor of Psychiatry, Yale University School of Medicine, New Haven, CT, 2005– present
Director, Yale Depression Research Program, Yale University School of Medicine, New Haven, CT
Selected Publications:
1. Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry. 2004. 61(7):705-13.
2. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP, et al. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology. 1992. 130(6):3608-16.
3. Sanacora G, Kershaw M, Finkelstein JA, White JD. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology. 1990. 127(2):730-7.

Entering Class of 1985:

Bunch, Bonnie L.
B.A. Hunter College of CUNY, 1983
M.D. and Ph.D. in Anatomical Sciences, 1990
Dissertation Title: "Diffusion of a Fluorescent Probe in a Monolayer of Cultured Mammalian Cells”
Mentor: Peter R. Brink, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Pediatrics, University of Colorado School of Medicine, Denver, CO, 1991-1993
Neurophysiology Residency: Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 1993-1996
Clinical Neurophysiology Fellowship: Albert Einstein Coll. of Med., Bronk, NY, 1996-1997
Current position: Assistant Professor, University of South Dakota, SD, 1997– present
1. Hawkins EC, Hansen B, Bunch BL, Use of animation-enhanced video clips for teaching abnormal breathing patterns.
J Vet Med Educ. 2003. 30(1):73-7.

Entering Class of 1984:

*Heidelberger, Ruth
B.S. Stony Brook University, 1984
M.D. and Ph.D. in Neuroscience, 1993
Dissertation Title: "Characterization and modulation of the calcium influx pathway in single synaptic terminals of isolated retinal bipolar neurons: a fura-2 & patch-clamp study"
Mentor: Gary Matthews, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany, 1993-1996
Research Fellowship: Postdoctoral felow, laboratory of Dr. Erwin Neher (Nobel Prize in Medicine, 1991)
Current position: Associate Professor with Tenure, Neurobiology and Anatomy, University of Texas Medical School, co-Director of the M.D./Ph.D. program, Director of the M.D./Ph.D. program Neurotrack, Houston Health Science Center.
Description of current clinical and/or research interests: Many diseases that afflict the nervous system are associated with deficits in neuronal communication. Using a combination of biophysical, computational and molecular approaches, Dr. Heidelberger studies the presynaptic mechanisms that participate in neuronal communication. She specializes in the study of neurotransmitter exocytosis and synaptic vesicle dynamics in neurons of the vertebrate retina.
Selected Publications:
1. Wan QF, Vila A, Zhou ZY, Heidelberger R. Synaptic vesicle dynamics in mouse rod bipolar cells. Vis Neurosci. 2008. 25(4):523-33.
2. Innocenti, B and Heidelberger, R. Mechanisms contributing to tonic release at the cone photoreceptor ribbon synapse. Journal of Neurophysiology. 2008. 99(1):25-36.
3. Heidelberger R. Neuroscience: sensors and synchronicity. Nature. 2007. 450(7170):623-5.
4. Heidelberger R. Mechanisms of tonic, graded release: lessons from the vertebrate photoreceptor. J Physiol. 2007. 585(Pt 3):663-7.

*Jay, Gregory D.
B.E. / B.S. Stony Brook University, 1984
M.D. and Ph.D. in Cellular and Molecular Pathology, 1990
Dissertation Title: "Joint Lubrication: A Physicochemical Study of a Purified Lubricating Factor from Bovine Synovial Fluid”
Mentor: Leon Sokoloff, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Emergency Medicine, Unv. Massachusetts Medical School, Worcester, MA
Selected Publications:
1. Shapiro MJ, Gardner R, Godwin SA, Jay GD, Lindquist DG, Salisbury ML, Salas E. Defining team performance for simulation-based training: methodology, metrics, and opportunities for emergency medicine. Acad Emerg Med. 2008. 15(11):1088-97.
2. Taguchi M, Sun YL, Zhao C, Zobitz ME, Cha CJ, Jay GD, An KN, Amadio PC. Lubricin surface modification improves tendon gliding after tendon repair in a canine model in vitro. J Orthop Res. 2008. 27(2):257-263.
3. Jay GD, Lane BP, Sokoloff L. Characterization of a bovine synovial fluid lubricating factor. III. The interaction with hyaluronic acid. Connect Tissue Res. 1992. 28(4):245-55.

Lee, Hyun-Soo
M.D. and Ph.D. in Pathology, 1990
Mentor: Gail Habicht, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Albert Einstein College of Medicine, Bronx, NY, 1990-1991
Clinical Fellowship: Dermatology, New York University School of Medicine, New York, NY, 1991-1994
Research Fellowship: Dermatology, New York University School of Medicine, New York, NY, 1994-1995
Current position: Clinical Instructor of Dermatology, New York University School of Medicine, New York, NY

Parsons, Ramon E.
A.B. Columbia University, 1983
M.D. and Ph.D. in Molecular Genetics and Microbiology, 1992
Dissertation Title: "The SV40 Core Origin of DNA Replication"
Mentor: Peter Tegtmeyer, PhD, Stony Brook University, Stony Brook, NY
Current position: Avon Professor of Pathology and Medicine
Leader, Breast Cancer Program, Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York
Selected Publications:
1. Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R. Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science. 2009. 325(5945):1261-5.
2 . Parsons R, Tegtmeyer P. Spacing is crucial for coordination of domain functions within the simian virus 40 core origin of replication. J Virol. 1992. 66(4):1933-42.
3. Parsons RE, Stenger JE, Ray S, Welker R, Anderson ME, Tegtmeyer P. Cooperative assembly of simian virus 40 T-antigen hexamers on functional halves of the replication origin. J Virol. 1991. 65(6):2798-806.

*Richard, Robert E.
B.A. University of Pennsylvania, 1983
M.D. and Ph.D. in Molecular and Cellular Pharmacology, 1992
Dissertation Title: "Tissue Specific Isoforms of Topoisomerase I from Xenopus laevis"
Mentor: Daniel Bogenhagen, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, University of Maryland School of Medicine, Baltimore, MD, 1992-1995
Clinical Fellowship: Division of Hematology, University of Washington School of Medicine, Seattle, WA
Research Fellowship: Fred Hutchinson Cancer Research Center, Seattle, WA
Current position: Assistant Professor, Department of Medicine, Division of Hematology, Institute for Stem Cells and Regenerative Medicine, University of Washington School of Medicine of Medicine, Seattle, WA, 2003– present
Selected Publications:
1. Pandit SD, Richard RE, Sternglanz R, Bogenhagen DF. Cloning and characterization of the gene for the somatic form of DNA topoisomerase I from Xenopus laevis. Nucleic Acids Res. 1996. 24(18):3593-600.
2. Richard RE, Bogenhagen DF. The 165-kDa DNA topoisomerase I from Xenopus laevis oocytes is a tissue-specific variant.
Dev Biol. 1991. 146(1):4-11.
3. Richard RE, Bogenhagen DF. A high molecular weight topoisomerase I from Xenopus laevis ovaries. J Biol Chem. 1989. 15;264(8):4704-9.

Sugrue, Mary M.
B.A. Cornell University, 1984
M.D. and Ph.D. in Molecular Genetics and Microbiology, 1991
Mentor: Joan S. Brugge, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Pediatrics, Mount Sinai Medical Center, New York, NY
Current position: Assistant Professor, Pediatrics, Mount Sinai, New York, NY
Selected Publications:
1. Grothey A, Sugrue MM, Purdie DM, Dong W, Sargent D, Hedrick E, Kozloff M. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol. 2008. 26(33):5326-34.
2. Sugrue MM, Tatton WG. Mitochondrial membrane potential in aging cells. Biol Signals Recept. 2001. 10(3-4):176-88. Review. 3. Sugrue MM, Wang Y, Rideout HJ, Chalmers-Redman RM, Tatton WG. Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence. Biochem Biophys Res Commun. 1999. 261(1):123-30.

Weiss, Steven J.
B.S. SUNY Binghamton, 1984
M.D. and Ph.D. in Molecular & Cellular Pharmacology, 1991
Dissertation Title: "DNA Damage Effects on DNA Polymerase"
Mentor: Paul Fisher, M.D., Ph.D., Stony Brook University, Stony Brook, NY
Current position: Albert Einstein College of Medicine, Bronx, NY
Selected Publications:
1. Lehti K, Rose NF, Valavaara S, Weiss SJ, Keski-Oja J. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J Cell Sci. 2009. 122(Pt 1):126-35.
2. Weiss SJ, Ernst AA, Sills MR, Quinn BJ, Johnson A, Nick TG. Development of a novel measure of overcrowding in a pediatric emergency department. Pediatr Emerg Care. 2007. 23(9):641-5.
3. Weiss SJ, Fisher PA. Interaction of Drosophila DNA polymerase alpha holoenzyme with synthetic template-primers containing mismatched primer bases or propanodeoxyguanosine adducts at various positions in template and primer regions. J Biol Chem. 1992. 267(26):18520-6.

Entering Class of 1983:

Clynes, Raphael A.
B.S. M.I.T., 1983
M.D. and Ph.D. in Molecular Biology, 1990
Dissertation Title: "Rapid induction of IgM-secreting murine plasmacytomas by pristane and an immunoglobulin heavy-chain promoter/enhancer-driven c-myc/v-Ha-ras retrovirus"
Mentor: Kenneth B. Marcu, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis, MO
Current position: Assistant Professor in Medicine and Microbiology, Gail Williams Biomedical Scholar in Medicine, co-Director Immunology Program, Columbia University Irving Cancer Center, New York, NY
Description of current clinical and/or research interests: Our research program is based on understanding the immunobiology of Fc receptor function. Fc receptors (FcRs) link the cellular and humoral response in both the sensitization and effector phases of the immune response. In the sensitization phase FcRs function as antigen-uptake receptors on antigen presenting cells, including dendritic cells, while their expression on myeloid effector cells and NK cells mediate antibody-mediated effector inflammatory and cytotoxic responses.
Selected Publications:
1. Schirmer DA, Song SC, Baliff JP, Harbers SO, Clynes RA, Krop-Watorek A, Halverson GR, Czerwinski M, Spitalnik SL. Mouse models of IgG- and IgM-mediated hemolysis. Blood. 2007. 109(7):3099-107.
2. Curcio C, Di Carlo E, Clynes R, Smyth MJ, Boggio K, Quaglino E, Spadaro M, Colombo MP, Amici A, Lollini PL, Musiani P, Forni G. Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas. J Clin Invest. 2003. 111(8):1161-70.
3. Trcka J, Moroi Y, Clynes RA, Goldberg SM, Bergtold A, Perales MA, Ma M, Ferrone CR, Carroll MC, Ravetch JV, Houghton AN. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity. 2002. 16(6):861-8.
4. Rafiq K, Bergtold A, Clynes R. Immune complex-mediated antigen presentation induces tumor immunity. J Clin Invest. 2002. 110(1):71-9.
The Dec 1st issue of Nature: Research Highlights features a piece on work done by Raphael Clynes at Columbia--work on dendritic cells.

Entering Class of 1982:

Randazzo, Bruce, P.
B.S. University of Arizona, 1981
M.D. and Ph.D. in Pathology, 1988
Mentor: Berhane Ghebrehiwet, D.V.M., D.Sc., Stony Brook University, Stony Brook, NY
Residency: Dermatology, New York University Medical Center, New York, NY
Selected Publications:
1. Tal-Singer R, Pichyangkura R, Chung E, Lasner TM, Randazzo BP, Trojanowski JQ, Fraser NW, Triezenberg SJ. The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous systems. Virology. 1999. 259(1):20-33.
2. Randazzo BP, Tal-Singer R, Zabolotny JM, Kesari S, Fraser NW. Herpes simplex virus 1716, an ICP 34.5 null mutant, is unable to replicate in CV-1 cells due to a translational block that can be overcome by coinfection with SV40. J Gen Virol. 1997. 78 ( Pt 12):3333-9.
3. Randazzo BP, Bhat MG, Kesari S, Fraser NW, Brown SM. Treatment of experimental subcutaneous human melanoma with a replication-restricted herpes simplex virus mutant. J Invest Dermatol. 1997. 108(6):933-7.

Uht, Rosalie, M.
B.A. University of California, San Francisco, 1976
M.D. and Ph.D. in Neuroscience, 1990
Dissertation Title: "Glucocorticoid Regulation of Corticotropin-releasing Factor"
Mentor: Jeffrey F. McKelvy, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Pathology, PGYI, Dept. of Anatomic Pathology, University of California, San Francisco, CA, 1990-1991
Chief Resident: VAMC San Francisco, Anatomic Pathology, 1991
Pathology Resident, PGYII, Dept. of Anatomic Pathology, University of California, San Francisco, CA, 1991-1992
Neuropathology Fellow year I, Dept. of Anatomic Pathology, University of California, San Franciso, CA, 1992-1993
Research Fellow: Dept. of Anatomic Pathology & Metabolic Research Unit, UCSF, & Neuropathology Fellow year II, Dept. of Anatomic Pathology, UCSF, 1993-1994
Post Graduate Researcher, Metabolic Research Unit & Clinical Instructor without salary, Dept. of Pathology (Neuropathology), UCSF, 1994-1995
Current position: Assistant Professor, Pathology, University of Virginia, VA
Selected Publications:
1. Lalmansingh AS, Uht RM. Estradiol regulates corticotropin-releasing hormone gene (crh) expression in a rapid and phasic manner that parallels estrogen receptor-alpha and -beta recruitment to a 3',5'-cyclic adenosine 5'-monophosphate regulatory region of the proximal crh promoter. Endocrinology. 2008. 149(1):346-57.
2. Uht RM, Amos S, Martin PM, Riggan AE, Hussaini IM. The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway. Oncogene. 2007. 26(20):2885-93.
3. Uht RM, McKelvy JF, Harrison RW, Bohn MC. Demonstration of glucocorticoid receptor-like immunoreactivity in glucocorticoid-sensitive vasopressin and corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus. J Neurosci Res. 1988. 19(4):405-11, 468-9.

Entering Class of 1978:

Kaplan, Leonard J.
B.A. University of Pennsylvania, 1978
M.D. and Ph.D. in Molecular Genetics and Microbiology, 1986
Mentor: Arnold Levine, Ph.D., Stony Brook University, Stony Brook, NY
Residency: Internal Medicine, University of Chicago, Chicago, IL
Selected Publications:
1. Maerz L, Kaplan LJ. Abdominal compartment syndrome. Crit Care Med. 2008. 36(4 Suppl):S212-5. Review.
2. Kellum JA, Cerda J, Kaplan LJ, Nadim MK, Palevsky PM. Fluids for prevention and management of acute kidney injury. Int J Artif Organs. 2008. 31(2):96-110.
3. Kaplan LJ, Kellum JA. Comparison of acid-base models for prediction of hospital mortality after trauma. Shock. 2008. 29(6):662-6.

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