Danny Khalil

4th Year Graduate Student

Department: Cold Spring Harbor Laboratory

Graduate Program: Genetics

Advisor: Dr. Bill Tansey

Abstract:

Title: The MBP1-Myc interaction as a unique determinant of malignancy in prostate cancer

A conserved region within the myc oncoprotein, Myc box III (MbIII), is known to affect myc function. However, little is known about the how MbIII does so. To understand MbIII's mechanism of action we are currently screening for proteins that specifically interact with this region. We are also investigating a possible link between MbIII and normal metabolic pathways that are altered in cancer. Finally, we are determining whether MbIII plays a role in a specific type of myc proteolysis.    

Publications:
(MSTP-supported publications indicated with an *)

Petrov AI, Khalil DN, Kazaryan RL, Savintsev IV, Sukhorukov B (2002). Structural and thermodynamic features of complexes formed by DNA and synthetic polynucleotides with dodecylamine and dodecyltrimethylammonium bromide. Bioelectrochemistry. 58(1):75-85.