

Ph.D.: National Taiwan University, Taiwan
Postdoctoral Fellowship: University of Texas MD Anderson Cancer Center
Tumor heterogeneity is frequently displayed in human cancers. This phenotype can be attributed to two mechanisms–cancer cell clonal evolutions and propagation of cancer stem cells (CSCs). CSCs, despite of the rareness, are known as a major contributor for drug resistance, tumor relapse and consequently cancer death. Two hallmarks of cancer are known to orchestrate CSC dormancy and reaction: 1) Epithelial-mesenchymal transition (EMT) and 2) Dysregulated metabolism. My laboratory focuses on deciphering regulatory machinery and mechanism (e.g. E3 ubiquitin ligase and ubiquitination, metabolic enzymes and drivers, etc.) responsible for EMT and dysregulated metabolism in cancer cells and CSCs. Besides the neoplastic cancer cells, lymphocytes and macrophages are prominent residents in tumor microenvironment. My laboratory also investigates the mechanisms underlying the tumor immunity. The ultimate goal is to develop the mechanism-based cancer therapeutics. We use complementary approaches including cell biological and biochemical methods, informatics tools, animal models (xenograft, syngeneic, genetically-modified, PDX and humanized mice), and clinical specimens to interrogate the following research projects:
For a complete list of current publications please click HERE.
Selected publications (#First, *Corresponding author): 3200 citations; h-index=25; h-10 index= 28
1. Zhang S, Lin HK, Chan CH, Morrow JK. Small Molecule Inhibitors Targeting the SKP2 Pathway for Cancer Treatment. US Provisional Patent application. (PATENT UTSC.P1114US.P1)
Research Group
Hong-Jen (Joshua) Lee
Senior Postdoctoral Associate
PhD: UT MD Anderson Cancer Center, TX
Hong-Jen.Lee@stonybrook.edu
Yi-Jye (EJ) Chern
Postdoctoral Associate
PhD: University of British Columbia, Vancouver, British Columbia, Canada
yi-jye.chern@stonybrook.edu
Jiabei He
Graduate student (MCP PhD Program)
AACR associate member and selected poster presenter
MS: Stony Brook University
jiabei.he.1@stonybrook.edu
Bruno Carvalho
Graduate student (MCP PhD Program)
Latin America Scholarship Program of American Universities (LASPAU), 2014-2018
MS: State University of New York (SUNY) at Albany
bruno.pereiradecarvalho@stonybrook.edu
Golbahar Sadatrezaei
Graduate student (MCP Master Program)
BS: Stony Brook University
golbahar.sadatrezaei@stonybrook.edu
Chia-Hsin (Lori) Chan Ph.D.
Associate Professor
Department of Pharmacological Science
Basic Science Tower 8-121
Stony Brook University
Stony Brook, NY 11794-8651
Phone: 631-444-3085 (Office); 631-444-9743 (Lab)
E-Mail: chia-hsin.chan@stonybrook.edu