Ph.D. 1952, Harvard University
William Van der Kloot is interested in synaptic transmission, using the
frog and mouse neuromuscular junctions as models. The transmitter,
acetylcholine, is packaged in vesicles in the nerve terminal.
Transmitter is released by exocytosis, both spontaneously and at a
greatly increased rate following nerve stimulation. Van der Kloot and
his laboratory group study the mechanism for loading acetylcholine into
the vesicles, the regulation of the quantity loaded by hormones, drugs,
and other treatments. They are also investigating the kinetics of the
release of transmitter quanta following nerve stimulation.