Jillian C. Nissen, Postdoctoral Research Associate

631-444-3055  jillian.cypser@stonybrook.edu
The Role of Tuftsin and its Receptor Neuropilin-1 in the Attenuation of Experimental Autoimmune Encephalomyelitis
  • Biography

Research Description:

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by progressive demyelination and degeneration of neurons. In experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, we have shown that infusion of the small peptide tuftsin attenuates disease symptoms and shortens the disease course. I aim to determine if the beneficial effects of tuftsin are mediated through its receptor Nrp-1, and further elucidate the mechanism of tuftsin's action.