Graduate Program

Jennifer Schrandt, BS

jennifer.schrandt@stonybrook.edu
The role of alkaline ceramidase 3 in neural control of micturition
  • Biography
In May of 2012 I received my B.S. in Biology from Ursinus College, a small liberal arts school outside of Philadelphia. I started research in developmental biology during my freshman year, under the direction of Dr. Rebecca Lyczak. I studied the role of PAM-1 in anterior-posterior axis establishment in C. elegans for four years, during which I was published and received the Barry Goldwater Scholarship. I also participated in the Summer Undergraduate Research Program at Thomas Jefferson University during the summer of 2011, where I studied novel endogenous flu epitopes under the direction of Dr. Laurence Eisenlohr.

Publications:
Ruijuan Xu*, Kai Wang*, Yong Z Gong, Jennifer Schrandt, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D Spyropoulos, Mingsong Li, Jie Zhou, Ashley J Snider, Yusuf A Hannun, Lina M Obeid, and Cungui Mao (2016). “Alkaline ceramidase 3 (Acer3) deficiency aggravates colitis and colitis-associated tumorigenesis in mice by promoting expression of proinflammatory cytokines in cells of the innate immune system.” Cell Death & Disease. 7, e2124.

Kai Wang*, Ruijuan Xu*, Jennifer Schrandt*, Prithvi Shah*, Yong Z Gong*, Chet Preston, Louis Wang, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D Spyropoulos, Soyoung Rhee, Mingsong Li, Jie Zhou, Shaoyu Ge, Guofeng Zhang, Ashley J Snider, Yusuf A Hannun, Lina M Obeid, and Cungui Mao (2015). “Alkaline ceramidase 3 deficiency results in Purkinje cell degeneration and cerebellar ataxia due to dyshomeostasis of ceramides and their metabolites in the brain.” PLOS Genetics. 11(10), e1005591.

S. M. Fortin, S. L. Marshall, E. C. Jaeger, P. E. Greene, L. K. Brady, R. E. Isaac, J. C. Schrandt, D. R. Brooks, R. Lyczak (2010). "The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos." Developmental Biology. 344 (2): 992-1000.