Min-Guk Cho

DNA damage can generate danger signals that activate innate immune responses against tumors. However, cancer cells often suppress, redirect, or escape these signals, limiting the effectiveness of radiation therapy, DNA repair-targeted treatments, and immunotherapy. Our laboratory investigates the molecular and cellular mechanisms that determine whether damaged tumor cells activate antitumor immunity or evade immune control. More specifically, we aim to:

To address these questions, we combine screening-based approaches with cancer cell models, CRISPR-based tools, reporter systems, imaging, immune profiling, extracellular communication studies, and in vivo models.