Styliani-Anna (Stella)
E.
Tsirka
PhD
SUNY Distinguished Professor

 

PhD, Biochemistry, Aristotle University of Thesssaloniki, Greece

B.S., Chemistry, Aristotle University of Thesssaloniki, Greece

Phone
631-444-3859
Neuro-immune interactions: Cross-talk between the nervous and immune systems in health and disease

The central nervous system (CNS) was thought to be ‘immune privileged’ and not interact with the immune system. Recent evidence however suggests that many chronic neurodegenerative diseases, as well as many acute injuries in the CNS, are characterized by the presence and actions of inflammatory cells. An initial response to neuronal injury is evidenced by the rapid response of CNS microglia, which are antigen-presenting, immune-competent, myeloid cells that reside in the CNS and are able to modulate neuronal survival, or affect neuronal structural changes occurring in response to neuronal activity. Our research interests concern the communication, signaling events and cell-cell interactions between cells in the CNS parenchyma and microglia in the physiological and pathological CNS. We currently use in the lab models of glioblastoma (GBM), stroke, and chronic stress to probe these interactions. 

Stella Tsirka was born and raised in Greece. She received her BS and PhD degrees from the Aristotle University of Thessaloniki. After pursuing postdoctoral studies at Univ California San Francisco and SUNY Stony Brook, under the mentoring of Drs Phil Coffino and Sid Strickland, respectively, she became a Research Assistant Professor in the Department of Psychiatry at SBU in 1998, and then joined the Pharmacology faculty in 2000 as an Assistant Professor. Dr. Tsirka's research has focused on the study of (neuro)inflammatory processes in models of neurological and neuropsychiatric diseases. Specifically, the lab explores the function and activation of microglia, the immunocompetent cells of the CNS, in response to both physiological and pathological stimuli, using different models of disease including ones for multiple sclerosis, stroke, glioma, epilepsy as well as major depression disorder to investigate neuro-immune interactions and pathways common to them. Her investigations seek to identify targets for intervention and therapeutic treatment of these diseases. Dr. Tsirka has been the director of graduate training programs supported by NIH and NSF (IGERT), including the T32-funded Pharmacology Graduate Program and the T32-funded Scholars in BioMedical Sciences (Molecular Medicine) Program. She served as Vice Provost for Faculty Affairs (2014-2019). She serves currently as the Vice Dean for Faculty Affairs (since 2020), and is the Miriam and David Donoho Endowed Professor and Head of the Academy of Clinical and Educational Scholars (ACES), which is designed to advance faculty efforts to transform medical education in RSOM. She is currently the Secretary of the ASPET Task Force on Inclusion, Diversity, Equity, and Accessibility. She has received the SUNY Chancellor’s Award for Excellence in University Service, the Mentor of Excellence Award from the SBU Center for Inclusive Education, and was elected a Fellow of the American Association for the Advancement of Science (AAAS).

1. Shifman SG, O'Connor JL, Radin DP, Sharma A, Infante L, Ferraresso F, Kastrup CJ, Lawrence DA, Tsirka SE. Targeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma. J Exp Clin Cancer Res. 2025 Jul 19;44(1):214. PMID: 40684232; PMCID: PMC12275254
2. Madeira MM, Hage Z, Kokkosis AG, Nnah K, Guzman R, Schappell LE, Koliatsis D, Resutov E, Nadkarni NA, Rahme GJ, Tsirka SE. Oligodendroglia Are Primed for Antigen Presentation in Response to Chronic Stress-Induced Microglial-Derived Inflammation. Glia. 2025 Jun;73(6):1130-1147. PMID: 39719686; PMCID: PMC12014386
3. Hage Z, Madeira MM, Koliatsis D, Tsirka SE. Convergence of endothelial dysfunction, inflammation and glucocorticoid resistance in depression-related cardiovascular diseases. BMC Immunol. 2024 Sep 27;25(1):61. doi: 10.1186/s12865-024-00653-9. PMID: 39333855; PMCID: PMC11428380
4. Radin DP, Shifman S, Outhwaite IR, Sharma A, Bases R, Seeliger MA, Tsirka SE. Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. J Pharmacol Exp Ther. 2024 Mar 15;389(1):51-60.  PMID: 38296645; PMCID: PMC10949164
5. Kokkosis AG, Madeira MM, Hage Z, Valais K, Koliatsis D, Resutov E, Tsirka SE. Chronic psychosocial stress triggers microglial-/macrophage-induced inflammatory responses leading to neuronal dysfunction and depressive-related behavior. Glia. 2024 Jan;72(1):111-132. . PMID: 37675659; PMCID: PMC10842267
6. Frohman DFT, Nnah K, Tsirka SE. Intersection of Sex and Depression: Pathogenesis, Presentation, and Treatments. Handb Exp Pharmacol. 2023;282:163-180. PMID: 37439845; PMCID: PMC11519624
7. Victor TR, Hage Z, Tsirka SE. Prophylactic Administration of Cannabidiol Reduces Microglial Inflammatory Response to Kainate-Induced Seizures and Neurogenesis. Neuroscience. 2022 Sep 15;500:1-11. Epub 2022 Jun 11. PMID: 35700815
8. Radin DP, Smith G, Moushiaveshi V, Wolf A, Bases R, Tsirka SE. Lucanthone Targets Lysosomes to Perturb Glioma Proliferation, Chemoresistance and Stemness, and Slows Tumor Growth In Vivo. Front Oncol. 2022 Apr 14;12:852940.  PMID: 35494072; PMCID: PMC9048484
9. Kokkosis AG, Madeira MM, Mullahy MR, Tsirka SE. Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination. Mol Psychiatry. 2022 Jun;27(6):2833-2848. PMID: 35301426; PMCID: PMC9169792
10. Caponegro MD, Oh K, Madeira MM, Radin D, Sterge N, Tayyab M, Moffitt RA, Tsirka SE. A distinct microglial subset at the tumor-stroma interface of glioma. Glia. 2021 Jul;69(7):1767-1781. PMID: 33704822; PMCID: PMC8113099

A complete list of publications can be found in HERE.

Current Members
Kimberly Nnah, PhD Graduate student (kimberly.nnah@stonybrook.edu)
Labiba Aziz, PhD Graduate student (labiba.aziz@stonybrookmedicine.edu)
Stuti Kumar, MS Graduate student (stuti.kumar@stonybrook.edu)
Gabriella Garber, Undergraduate student
Soled Liberius, Undergraduate student
Katerina Balca, Undergraduate student

Recent Alumni 
Doctoral Trainees
Dr. Zachary Hage
Dr. Sophie Shifman
Dr. Miguel Madeira
Dr. Daniel Radin
Dr. Tanya Victor
Dr. Alexandros Kokkosis

Stella Tsirka

Department of Pharmacological Sciences 

BST8, Rm 192 Stony Brook University 

Stony Brook, NY 11794-8651

Tel: 631-444-3859

Fax: 631-444-9749

Email: styliani-anna.tsirka@stonybrook.edu