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CRAIG MALBON: Publications
CRAIG C. MALBON, PH.D., M.DIV., FAAAS, FRSM
Leading Professor
Ph.D., Case Western Reserve University
Postdoctoral training: Brown University, Division of Biology & Medicine;
Department of Biology, Harvard University
Visiting Scholar, Princeton Theological Seminary
M. Div. (Ethics), Union Theological Seminary in New York City
Fellow, Center for Medical Humanities, Compassionate Care, & Bioethics
Department of Family, Population, & Preventive Medicine
631-444-3077 craig.malbon@stonybrook.edu
Signal Transduction in Differentiation and Development: Roles of Molecular Scaffold Molecules (e.g., AKAPs and Dishevelleds)
Recent Publications (selected from 275+ publications, since 2005)
279. Malbon, C.C. (2017)
Virtue Ethics & Medicine, a “New” Perspective
J. Bioethics: in process.
278. Malbon, C. C. and Wang, H.Y. (2017)
Isolation and Interrogation of Supermolecular Signalsome Complexes by Steric-
exclusion Chromatography.
(in "Transmembrane Signaling Protocols” of Methods in Molecular Biology
Humana/Springer Publishers)
1: 000-000, in the press
277. Malbon, C.C. (2017)
From Bench to Bedside: Biochemist, Ethicist, Pastor, & Chaplain
ASBMB Today, 12, 34-38.
276. Bertalovitz, A.C., Pau, M.S., Gao, S., Malbon, C.C., and Wang, H.Y. (2016)
Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal
Dishevelled Recruitment and Norrin-stimulated Activation of
Lef/Tcf-dependent Transcriptional Activation
J. Mol. Signaling, 11:
275. Pau, M.S., Gao, S., Malbon, C.C., Wang, H.Y. and Bertalovitz, A.C. (2015)
F328S Frizzled-4 Implicated in Familial Exudative Vitreoretinopathy Displays
Impaired Ability to Recruit Dishevelled
J. Mol. Signaling, 10: 1-10.
274. Malbon, E.R. and Malbon, CC (2015)
Gathering Thoughts (book)
CreateSpace Independent Publishing, Inc. (North Carolina) 130 pp.
273. Gao, S., Malbon, C.C., and Wang, H.Y. (2014)
Probing the Stoichiometry of Beta2-adrenergic Receptor Phosphorylation
by Targeted Mass Spectrometry
J. Mol. Signaling, 9: 3-18.
272. Malbon, C.C. (2013) Library of Congress United States Copy Right Office 2012
Abortion in 21st Century America (Book)
CreateSpace Independent Publishers (North Carolina), pp 266
271. Bikkavilli, R.K., Avasarala, S., Vanscoyk, M., Scheler, M., Kelley, N.,
Malbon, C.C., and Winn, R.A. (2012)
Dishevelled3 is a Novel Arginine Methyl Transferase Substrate.
Scientific Reports (Nature) 2: 805-811.
270. Bikkavilli, R.K., and Malbon, C.C. (2012)
Wnt3a-stimulated Arginine Methylation & LRP6 Phosphorylation.
J. Cell Sci., 125:2446-2456.
269. Kocer, S., Wang, H.Y., and Malbon, C.C. (2012)
“Shaping” of Cell Signaling via AKAP-tethered PDE4D: Probing with AKAR2-AKAP5 Biosensor.
J. Mol. Signaling, 7: 4-15. [See editorial commentary on article in Current Biology.]
268. Yokoyama, N., Markova, N.G., Wang, H.Y., and Malbon, C.C. (2012)
Assembly of Dishevelled 3-based Supermolecular Complexes via
Phosphorylation and Axin.
J. Mol. Signaling, 7: 8-26.
267. Wang, H.-Y., and Malbon, C.C. (2012)
Dishevelled C-terminus: Structural Insights.
Acta Physiolog., 196: 65-73.
266. Goa, S., Wang, H.-y., and Malbon, C. C. (2011)
AKAP5 and AKAP12 Form Higher-Order Hetero-oligomers
J. Mol. Signaling 6: 8-20.
265. Goa, S., Wang, H.-y., and Malbon, C. C. (2011)
AKAP5 and AKAP12 Form Homo-oligomers
J. Mol. Signaling 6: 3-13.
264. Bikkavilli, R.K., and Malbon, C. C. (2011)
Arginine Methylation of G3BP1 by Wnt3a Regulates b-catenin mRNA.
J. Cell Sci.124: 2310-2320.
263. Wang, H.-y., and Malbon, C. C. (2011)
Dishevelled C-terminus: Structural Insights
Acta Physiolog. 195: 1748-1754.
262. Malbon, C. C. (2011)
Wnt Signaling: The Case of the “Missing” G Protein
Biochem. J. 433: 3-6.
261. Wang, H. -y., and Malbon, C. C. (2011)
Probing the Physical Nature and Composition of Signalsomes
J. Mol. Signal. 6: 1-10.
260. Ma, L., Wang, Y., Malbon, C. C., and Wang, H.-y. (2010)
Dishevelled-3 C-terminal His Single Amino Acid Repeats are Obligate for Wnt5a Activation of
Non-canonical Signaling
J. Mol. Signal. 5: 19-29.
259. Yokoyama, N., Golebiewska, U., Wang, H.-y., and Malbon, C. C. (2010)
Wnt-dependent Assembly of Supermolecular Dishevelled 3-based Complexes
J. Cell Science 123: 3693-3702. (see “In This Issue” for highlights)
258. Tao, J., Wang, H.-y., and Malbon, C. C. (2010)
AKAR2-AKAP12 Fusion Protein “Biosenses” Dynamic Phosphorylation and Localization of a GPCR-based
Scaffold
J. Mol. Signaling 5: 17-39.
257. Bikkavilli, R.K., and Malbon, C. C. (2010)
Dishevelled-KSRP Complex Regulates Wnt Signaling through Post-transcriptional Stabilization of Beta-catenin
mRNA
J. Cell Science 123: 1352-1362.
256. Yokoyama, N., and Malbon, C. C. (2009)
Dishevelled-2 Docks and Activates Src in a Wnt-dependent Manner.
J. Cell Science 122: 4439-4451.
255. Bikkavilli R.K., and Malbon, C. C. (2009)
Mitogen-activated Protein Kinases and Wnt/b-Catenin Signaling: Molecular Conversations among Signaling
Pathways
Commun Integr Biol. 2:46-49.
254. Chen, M.-h., and Malbon, C. C. (2009)
G-protein-coupled Receptor-Associated A-kinase Anchoring Proteins AKAP5 and AKAP12: Differential Trafficking
and Distribution.
Cell Signal. 21:136-142.
253. Tao, J., and Malbon, C. C. (2008)
b-Adrenergic Receptor Recycling is Catalyzed by AKAP12, not AKAP5
J. Mol. Signal. 3: 329-339.
252. Bikkavilli, R.K., Feigin, M. E., and Malbon, C. C. (2008)
p38 Mitogen-activated Protein Kinase Regulates Canonical Wnt/b-catenin Signaling by Inactivation of GSK3b
J. Cell Science 121: 3598-3607.
251. Okoye, U.C., Malbon, C. C., and Wang, H.-y. (2008)
Wnt and Frizzled RNA Expression in Human Mesenchymal and Embryonic (H7)
Stem Cells (PubMed “highly accessed article”)
J. Mol. Signal. 3:16-22.
250. Ma, Y., Malbon, C. C., Williams, D.L., and Thorngate, F. (2008)
Aortic Lesions and Altered Gene Expression of Early Stage Atherosclerosis are Blocked by Low Levels of ApoE
PLoS, 3: 2503-2512.
249. Feigin, M. E., and Malbon, C. C. (2008)
OSTM1 Regulates Beta-catenin/Lef1 Interaction and is Required for Wnt/beta-catenin Signaling
Cell Signal. 20: 949-958.
248. Bikkavilli, R.K., Feigin, M. E., and Malbon, C. C. (2008)
G-protein Galpha o Mediates Wnt/c-Jun N-terminal Kinase Signaling through Dvl1,3/RhoA Family
Members/MEKK1,4 in Mammalian Cells
J. Cell Science 121: 234-245.
247. Yokoyama, N., and Malbon, C. C. (2007)
Phosphoprotein Phosphatase 2A Docks to Dishevelled and Counterregulates Wnt3a/beta-catenin Signaling
J. Mol. Signal. 2: 2-20.
246. Yokoyama, N., and Malbon, C. C. (2007)
Abundance, Complexation, and Trafficking of Wnt/beta-catenin Signaling Elements in Response to Wnt3a
J. Mol. Signal. 2: 11-27.
245. Feigin, M., and Malbon, C. C. (2007)
RGS19 Regulation Wnt/b-catenin Signaling through Inactivation of Gao.
J. Cell Science 120: 3404-3414.
244. Malbon, C. C. (2007)
A-Kinase Anchoring Proteins: Trafficking in G-protein-coupled Receptors and the Proteins that Regulate
Receptor Biology
Curr. Opin. Drug Discov. Devel. 10: 573-579.
243. Shumay, E., Tao, J., Wang, H.-y., and Malbon, C. C. (2007)
Lysophosphatidic Acid Regulates Trafficking of Beta-adrenergic Receptors: the Ga13/p115RhoGEF/JNK
Pathway Stimulates Receptor Internalization
J. Biol. Chem. 282: 21529-21541.
242. Gavi, S., Yin, D., Shumay, E., Wang, H.-y., and Malbon, C. C. (2007)
IGF-1 Provokes Functional Antagonism and Internalization of Beta1-Adrenergic Receptors
Endocrinology 148: 2653-2662.
241. Yin, D., Gavi, S., Shumay, E., Wang, H.-y., and Malbon, C. C. (2006)
Yeast Ste2 Receptors as Tools for Study of Mammalian Protein Kinases and Adaptors Involved in Receptor
Trafficking
J. Molecular Signaling, 1: 2-8.
240. Tao, J., Shumay, E., Wang, H.-y., and Malbon, C. C. (2007)
Src Docks to A-kinase Anchoring Protein Gravin, Regulating Beta2-adrenergic Receptor Resensitization and
Recycling
J. Biol. Chem. 282: 6597-6608.
239. Tao, J., Shumay, E., McLaughlin, S., Wang, H.-y., and Malbon, C. C. (2006)
Regulation of AKAP-Membrane Interactions by Calcium
J. Biol. Chem. 281: 23932-29344.
238. Malbon, C. C., and Wang, H.-y. (2006)
Dishevelled: A Mobile Scaffold Catalyzing Development
Current Topics in Developmental Biology, 72: 153-178.
237. Wang, H.-y., Liu, T., and Malbon, C. C. (2006)
Structure-Function Analysis of Frizzleds
Cellular Signalling 18: 934-941.
236. Wang, H.-y., Tao, J., Shumay, E., and Malbon, C. C. (2006)
G protein-coupled Receptor-Associated A-kinase Anchoring Proteins: AKAP79 and AKAP250 (gravin)
Eur. J. Cell Biology 85: 643-650.
235. Gavi, S., Shumay, E., Wang, H.-y., and Malbon, C. C. (2006)
G protein Coupled Receptors and Tyrosine Kinases: Crossroads in Cell Signaling and Regulation
Trends in Endocrinology & Metabolism 17: 48-55.
234. Yin, D., Gavi, S., Shumay, E., Duell, K., Konopka, J.B., Malbon, C. C., and Wang, H.-y. (2005)
Successful Expression of a Functional Yeast G-protein-coupled receptor (Ste2) in Mammalian Cells
Biochem. Biophys. Res. Commun. 329: 281-287.
233. Gavi, S., Yin, D., Shumay, E., Malbon, C. C., and Wang, H.-y. (2005)
The 15-Amino Acid Motif of the C Terminus of the ß2-Adrenergic Receptor Is Sufficient to Confer Insulin-
Stimulated Counterregulation to the ß1-Adrenergic Receptor
Endocrinology 146: 450-457.
232. Malbon, C.C. (2005)
Beta-Catenin, Cancer, and G Proteins: Not just for Frizzleds Anymore
Science (STKE) 292, pe35.
231. Malbon, C. C. (2005)
G proteins in Development
Nature Reviews: (Molecular Cell Biology), 6: 689-701.
230. Malbon, C. C. and Wang, H.-y (2005)
AKAP-based Scaffolds and Insulin Action
Cell Science Rev. 12: 1742-1749.