Our lab investigates how nutritional environments reprogram mRNA translation to shape the proteome and metabolome, thereby influencing metabolic health, aging, and cancer. We integrate molecular biology, protein–metabolite interaction assays, ribosome profiling, metabolomics, and in vivo physiology to uncover how dietary cues and lipids dynamically regulate gene expression and cellular fate. Our goal is to define the mechanisms by which nutrient–gene crosstalk drives insulin resistance, cancer progression, and aging, and to translate these discoveries into novel therapeutic strategies.
Diet–Gene Crosstalk in Insulin Resistance & Aging
Lipid-Translation Interaction & Signaling
Dietary Interventions & Cancer Therapy
A complete list of publications can be found in HERE.
Haojun Yang, Ph.D.
Assistant Professor
Department of Pharmacological Sciences
Renaissance School of Medicine and the Cancer Center
Basic Sciences Tower 8