Qiuhua Yang

Qiuhua
Yang
Ph.D.
Assistant Professor
Basic Sciences Tower 8-183
Phone
678-975-5197
Metabolic regulation of retinal degeneration

Research Interest

Vision loss affects millions of people worldwide, significantly diminishing the quality of life and independence. Despite advancements in treatment, many retinal degenerative diseases remain incurable, underscoring the urgent need for deeper mechanistic insights and innovative therapeutic strategies.

Our lab investigates the metabolic and inflammatory mechanisms driving retinal degenerative diseases, aging-related pathologies, and ocular fibrosis. We focus on understanding the complex interactions among retinal pigment epithelial (RPE) cells, macrophages/microglia, endothelial cells, and fibroblasts, with an emphasis on how metabolic reprogramming and inflammation contribute to disease progression. The interplay among metabolism, inflammation, and epigenetics plays a crucial role in these processes, as metabolite imbalances can influence gene expression, ultimately affecting cell fate and proliferation.

Our current projects aim to characterize metabolic heterogeneity within tissues, identify novel metabolic regulators, and explore metabolic signaling between different cell types. We are particularly focused on dissecting the distinct yet overlapping mechanisms involved in both forms of age-related macular degeneration (AMD). In wet AMD, we study how aberrant angiogenesis and immune-driven remodeling lead to choroidal neovascularization (CNV) and subretinal fibrosis. In dry AMD, we investigate the mechanisms of RPE degeneration, chronic inflammation, and oxidative stress that culminate in geographic atrophy (GA). Across both forms, we examine how metabolic and inflammatory cues regulate the crosstalk among RPE cells, immune cells, and endothelial cells. We are also investigating how retinal ischemia—as seen in diabetic retinopathy (DR), retinopathy of prematurity (ROP), and other ischemic conditions—triggers maladaptive immune and metabolic responses that accelerate neurovascular damage and fibrosis.

Utilizing cutting-edge technologies—including spatial transcriptomics, spatial metabolomics, single-cell sequencing, optical and photoacoustic imaging, and cell-cell interaction profiling—we aim to elucidate the molecular pathways driving AMD, DR, ROP, and retinal ischemia. In parallel, we explore broader systemic connections through the eye-gut, eye-cardiovascular, and eye-kidney axes, leveraging the eye as a “window” into systemic disease mechanisms.

Our ultimate goal is to identify novel therapeutic targets to halt or reverse vision loss and uncover broader implications for systemic health. Our work is generously supported by the NIH/NEI, the Renaissance School of Medicine, and Stony Brook University.

We welcome collaborations across disciplines and invite enthusiastic undergraduate students, graduate students, MD/PhD trainees, ophthalmology residents and fellows, and postdocs to join our team. Our lab offers a supportive, interdisciplinary environment for trainees interested in vision science, immune-metabolism, and translational research.

EDUCATION AND RESEARCH EXPERIENCE                                                                                                 

09/2013 - 01/2019

Ph.D.

Chemical Genomics

Peking University, Beijing, China

09/2009 - 07/2013

B.S.

Biotechnology

Yunnan University, Kunming, Yunnan, China

 

RESEARCH TRAINING & EXPERIENCE                                                                                                 

12/2019 - 06/2025

Postdoctoral Fellow

Vascular Biology in Cardiovascular and Retinal Diseases

Mentors: Dr. Yuqing Huo, Dr. Ruth Caldwell, Vascular Biology Center, Medical College of Georgia at Augusta University

04/2019 - 11/2019

Research Assistant

Vascular Biology in Cardiovascular

Mentors: Dr. Yuqing Huo, Vascular Biology Center, Medical College of Georgia at Augusta University

08/2015 - 03/2019

Visiting Scholar

Vascular Biology in Cardiovascular

Mentors: Dr. Yuqing Huo, Vascular Biology Center, Medical College of Georgia at Augusta University

Faculty Academic Appointment                                                                 

07/2025 - ongoing

Tenure-track Assistant Professor

Pharmacological Sciences

Stony Brook University

 

AWARDS AND HONORS                                                                                  

  • 2025 the ARVO Foundation Travel Grant, Association for Research in Vision and Ophthalmology (ARVO)
  • 2024 Best late-stage postdoctoral fellow, Medical College of Georgia, Augusta University
  • 2023 K99/R00 Pathway to Independence Award, National Eye Institute, NIH
  • 2022 1st Place Presentation and Travel Award winner, Medical College of Georgia, Augusta University
  • 2021 Postdoctoral Fellowship Award, American Heart Association
  • 2021 Best presentation by postdoctoral fellow, Medical College of Georgia, Augusta University
  • 2021 3rd Place presentation winner, Medical College of Georgia, Augusta University
  • 2020 Best early career stage postdoctoral fellow, Medical College of Georgia, Augusta University
  • 2018 First Prize of Excellent Graduate Scholarship, Peking University
  • 2013 Undergraduate Scholarship, Yunnan University
  • 2012 Undergraduate Scholarship, Yunnan University
  • 2011 Undergraduate Scholarship, Yunnan University
  • 2010 Undergraduate Scholarship, Yunnan University

 

A complete list of publications can be found in HERE.