Training Faculty / Research

A

Neuroendocrine regulation of the hypothalamus-pituitary-gonad (HPG) axis

B

Brain response to traumatic, ischemic or inflammatory insults
Molecular and cellular basis of bacterial-host cell interactions
Mitochondrial Biology
Mitochondrial Molecular Biology
Chemical Biology, Enzymology, Bioinorganic Chemistry, and Spectroscopy
Single molecule spectroscopy; Coordination of post-synaptic glutamate receptor signaling by the MAGUK family of scaffolds.
Analyzing heterogeneity of cancer tissues

C

Postivie and Negative Regulation of T cell Receptor Signaling.
The research in our group centers around the concept of chemical biology
Associate Professor, Department of Pathology, Stony Brook Medicine
Physiology and Pharmacology of Isolated Cardiac Myocytes
Multiple Sclerosis, Neuropharmacology, Signaling, Stem Cells
Extracellular matrix in the brain: roles during development and during neurodegeneration

D

E

Tumor microenvironment; intravital imaging; tumor-associated myeloid cells; breast cancer
Stem cells; neurogenesis; imaging; signal transduction

F

Cancer, Cardiovascular, Diabetes, Fertility, Infectious Diseases, Lipid Biology, Metabolic Disorders, Mitochondrial Biology, Neuropharmacology, Signaling
Lipid Signaling: Roles in mitochondrial biology, spermatogenesis, diabetes, immune function, the CNS, platelet activation, and cancer; - Imaging Pancreatic β-cells using metabolomics and MRI.

G

DNA Damage Repair, Mitochondrial Biology
Mechanisms of mitochondrial gene expression/Mechanisms of DNA synthesis and repair
To examine the functional integration of new neurons into brain circuits
C1q receptor mediated cellular responses with particular emphasis on inflammation and microbial infection
X-ray crystallography, mechanistic biochemistry and protein design techniques to uncover the operating principles of energy-dependent proteolytic machines in mitochondria.
Chemical Biology
Molecular Carcinogenesis: Mechanisms of DNA Repair and Mutagenesis

H

Lipid mediators of cancer cell signaling

J

Novel biophotonic technologies for understanding complex biological systems at the nano-meter scale.
Structural Biology/CSHL

K

Biochemistry and Structural biology of RNA-Protein Interactions, Translational Control of Gene Expression, and Drug Discovery
Cancer, DNA Damage Repair
DNA replication and repair pathways in cancer therapy
Biotechnology, Biology.
Molecular Genetics & Microbiology/Stony Brook

L

Signaling: Cell Signaling, Cancer, Stem cells, Protein trafficking and Disease
Intracellular signaling molecules that regulate cell growth
How cells organize chromatin structure to accommodate and control gene expression.

M

Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy
Molecular basis of stem cell development and cancer pathogenesis
Pathology/Stony Brook
Molecular Physiology of Neuronal Firing Properties
Signal transduction by tyrosine kinases
The chemical makeup of tissue in disease using high-resolution infrared and x-ray imaging.
Bioinformatics, personalized medicine, pancreatic adenocarcinoma, mixture modeling.
Tumor Suppressor Gene Research: Mechanism of p53 Inactivation

P

Anesthesiology/Stony Brook

R

Signal Transduction and Activation of Gene Expression by Cytokines & Cellular Defense Responses to Viral Infection
Computational Research Projects in Cancer, HIV\AIDS, Influenza, and Method Development.
DNA Damage Repair
Genetic Analysis of Mammalian Oxidative DNA Damage Repair

S

Protein Structure and Function
Aging, Cancer, Chemical Biology, Signaling
Molecular Mechanism of Protein Kinase and Ubiquitin Ligase signaling in Cancer and Aging
Chemical Biology, Infectious Diseases, Lipid Biology
Membrane biosynthesis, structure & behavior in bacterial pathogenesis
The molecular characterization of benign, premalignant, and malignant lesions of the female genital tract
Computational Structural Biology

T

Cancer, Metabolic Disorders, Signaling, Stem Cells
Cell Signaling and Ciliogenesis in Mammalian Development, Health and Disease
Cancer, DNA Damage Repair
Structure and function of macromolecules in epigenetic regulation
Vertebrate Embryonic Development
Enzyme Mechanisms and Rational Drug Design
Cancer, Environmental Toxicology, Multiple Sclerosis, Neuropharmacology, Signaling, Stem Cells, Stroke
Neuro-immune interactions: Cross-talk between the nervous and immune systems in health and disease
Pancreatic cancer, experimental therapeutics, diagnostics, mouse models, cancer genetics

V

The mammalian T cell response to Salmonella enterica serovar Typhimurium.
Cerebrovascular pathology in Alzheimer’s disease and related disorders

W

Molecular biology and physiology of gap junction channels
Molecular Mechanisms of Synaptic Function in the Brain

Y

Identifying the causes and treatment of gastrointestinal malignancies.